{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:53:17Z","timestamp":1792000397388,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T00:00:00Z","timestamp":1653782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cannabidiol (CBD) and cannabidiolic acid (CBDA) are reported to have antinociceptive, immunomodulatory and anti\u2010inflammatory actions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine if CBD\/CBDA is an effective therapy for canine atopic dermatitis (cAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirty\u2010two privately owned dogs with cAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Prospective, randomised, double\u2010blinded, placebo\u2010controlled study. Concurrent therapies were allowed if remained unchanged. Dogs were randomly assigned to receive either 2\u2009mg\/kg of an equal mix of CBD\/CBDA (n\u00a0=\u00a017) or placebo for 4\u2009weeks. On Day (D)0, D14 and D28, Canine Atopic Dermatitis Extent and Severity Index, 4th iteration (CADESI\u201004) and pruritus Visual Analog Scale (pVAS) scores were determined by investigators and owners, respectively. Complete blood count, serum biochemistry profiles and cytokine bioassays were performed on serum collected on D0 and D28.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no significant difference in CADESI\u201004 from D0 to D14 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.42) or D28 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.51) in either group. pVAS scores were significantly lower for the treatment group at D14 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.04) and D28 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.01) and a significant change in pVAS from baseline was seen at D14 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.04) and not D28 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.054) between groups. There was no significant difference in serum levels of interleukin (IL)\u20106, IL\u20108,\n                      <jats:italic>monocyte chemoattractant protein<\/jats:italic>\n                      \u2010\n                      <jats:italic>1<\/jats:italic>\n                      , IL\u201031 or IL\u201034 between groups at D0 or D28. Elevated alkaline phosphatase was observed in four of 17 treatment group dogs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and clinical relevance<\/jats:title>\n                    <jats:p>CBD\/CBDA as an adjunct therapy decreased pruritus, and not skin lesions associated with cAD in dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.13077","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T21:19:33Z","timestamp":1653859173000},"page":"329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The effect of a mixed cannabidiol and cannabidiolic acid based oil on client\u2010owned dogs with atopic dermatitis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3643-5618","authenticated-orcid":false,"given":"Melissa","family":"Loewinger","sequence":"first","affiliation":[{"name":"Animal Dermatology and Allergy Specialists  Wayne NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Wakshlag","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine Cornell University  Ithaca NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bowden","sequence":"additional","affiliation":[{"name":"Animal Dermatology and Allergy Specialists  Wayne NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9610-9040","authenticated-orcid":false,"given":"Jeanine","family":"Peters\u2010Kennedy","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine Cornell University  Ithaca NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Animal Dermatology and Allergy Specialists  Wayne NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.f1134"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.00505"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani9090686"},{"issue":"2","key":"e_1_2_9_5_1","first-page":"638","article-title":"(\u2212)\u2010cannabidiolic acid, a still overlooked bioactive compound: an introductory review and preliminary research","volume":"25","author":"Formato 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