{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:16:55Z","timestamp":1792063015418,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cold atmospheric microwave plasma (CAMP) is a promising therapeutic option for treating skin infections and wounds. Changes in biophysical skin parameters and the tolerability in dogs after applying CAMP is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to evaluate the <jats:italic>in vivo<\/jats:italic> effects of CAMP on skin biophysical parameters [hydration, transepidermal water loss (TEWL) and surface temperature] and tolerability in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty client\u2010owned dogs with normal skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Cold atmospheric microwave plasma treatment was performed for 30\u2009s and 1, 2 and 4\u2009min, respectively, at different sites of normal canine skin in the inguinal area. Hydration, TEWL and surface temperature were measured five, three and three times, respectively, before and after CAMP application. After treatment, pain and adverse effects were evaluated using a modified Melbourne Pain Scale and the modified short form Glasgow Composite Measure Pain Scale (modified CMPS\u2010SF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Transepidermal water loss values significantly decreased with 4\u2009min of treatment, and hydration decreased significantly with 2\u2009min of treatment. Temperature increased significantly with increasing treatment time. For other parameters, no significant changes were observed. No significant pain response or adverse effects were observed in most dogs, aside from mild erythema in the treatment area after 4\u2009min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and clinical significance<\/jats:title><jats:p>Cold atmospheric microwave plasma treatment was well\u2010tolerated and did not significantly change canine skin biophysical parameters. CAMP achieves basic recommendations for safe use and is a potential therapeutic option for various skin diseases in dogs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13080","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T11:00:37Z","timestamp":1653908437000},"page":"363-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of cold atmospheric microwave plasma on skin physiological parameters and tolerability in dogs"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9295-1249","authenticated-orcid":false,"given":"Na\u2010Eun","family":"Lee","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Dermatology and the Research Institute for Veterinary Science, College of Veterinary Medicine Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9524-024X","authenticated-orcid":false,"given":"Yeong\u2010Hun","family":"Kang","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Dermatology and the Research Institute for Veterinary Science, College of Veterinary Medicine Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon\u2010Young","family":"Song","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Dermatology and the Research Institute for Veterinary Science, College of Veterinary Medicine Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7866-7778","authenticated-orcid":false,"given":"Seung\u2010Joon","family":"Baek","sequence":"additional","affiliation":[{"name":"Laboratory of Signal Transduction, College of Veterinary Medicine Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7113-0361","authenticated-orcid":false,"given":"Cheol\u2010Yong","family":"Hwang","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Dermatology and the Research Institute for Veterinary Science, College of Veterinary Medicine Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1088\/1367-2630\/11\/11\/115011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2013.0591"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.01.025"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2008.08.001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppap.200700154"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physrep.2013.05.005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2012.07857_suppl.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surfcoat.2004.07.034"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppap.200800021"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.5108538"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.2918980"},{"key":"e_1_2_9_13_1","first-page":"136","article-title":"Assessment of a correlation between canine atopic dermatitis extent and severity index (CADESI\u201003) and selected biophysical skin measures (skin hydration, pH, and erythema intensity) in dogs with naturally occurring atopic dermatitis","volume":"79","author":"Zaj\u0105c M","year":"2015","journal-title":"Can J Vet Res"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2006.00437.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00222.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2340\/0001555570245247","article-title":"Epidermal hydration and skin mechanics. 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