{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:14:47Z","timestamp":1788520487853,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Canine trunk\u2010dominant pemphigus foliaceus (PF) is mentioned rarely in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>The goal of this study was to provide clinical description of trunk\u2010dominant PF and to demonstrate the prevalence of serum antikeratinocyte, anti\u2010desmocollin\u20101 (DSC1) and anti\u2010desmoglein\u20101 (DSG1) antibodies, and determine their diagnostic value in this particular PF phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Clinically relevant information was collected from 31, 25 and 34 dogs with trunk\u2010dominant and facial PF and superficial pyoderma (SP), respectively. Sera from these dogs were tested for antikeratinocyte, anti\u2010DSC1 and anti\u2010DSG1 antibodies using indirect immunofluorescence on canine tissues and DSC1\u2010 and DSG1\u2010transfected cells. Sera from healthy dogs and dogs with clinically irrelevant diseases served as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Footpad involvement and grouped\/polycyclic lesion organisation were identified as features of both PF phenotypes, and not of SP. Antikeratinocyte immunoglobulin (Ig)G was not specific for canine PF. By contrast, antigen\u2010specific IgG was detected only in PF sera; anti\u2010DSC1 IgG in 100% and 58% of dogs with facial and trunk\u2010dominant PF, respectively, and anti\u2010DSG1 IgG in 7% of dogs with trunk\u2010dominant PF only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Trunk\u2010dominant PF shares DSC1 as a major autoantigen with facial PF. The ability to detect anti\u2010DSC1 IgG is lower in trunk\u2010dominant PF, yet despite the lower sensitivity, the positive predictive value and accuracy of this particular anti\u2010DSC1 IgG test are high. A negative test result, however, cannot exclude the diagnosis, and characteristic clinical features such as footpad involvement and\/or grouped\/polycyclic lesions must be considered when distinguishing trunk\u2010dominant PF from its most relevant differential diagnosis: SP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13094","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T13:40:51Z","timestamp":1654609251000},"page":"414-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Trunk\u2010dominant and classic facial pemphigus foliaceus in dogs \u2013 comparison of anti\u2010desmocollin\u20101 and anti\u2010desmoglein\u20101 autoantibodies and clinical presentations"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8629-0528","authenticated-orcid":false,"given":"Petra","family":"Bizikova","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine NC State University  Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2970-2992","authenticated-orcid":false,"given":"Keith E.","family":"Linder","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology, College of Veterinary Medicine NC State University  Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa B.","family":"Mamo","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine NC State University  Raleigh NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"59","article-title":"Pemphigus foliaceus in dogs: a review of 37 cases","volume":"186","author":"Ihrke PJ","year":"1985","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2006.00540.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2004.224.1312"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/9780470752487","volume-title":"Skin Diseases of the Dog and Cat, Clinical and histopathologic diagnosis","author":"Gross TL","year":"2005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00821.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(83)90031-4"},{"key":"e_1_2_9_8_1","first-page":"424","article-title":"Immune\u2010mediated dermatoses in domestic animals: ten years after","volume":"9","author":"Scott DW","year":"1987","journal-title":"Part I. 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