{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:07:07Z","timestamp":1747188427705,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Information on acute\u2010phase protein (APP) concentrations in dogs with sarcoptic mange (SM) is scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the effects of the clinical severity of disease and concomitant pyoderma on serum C\u2010reactive protein (CRP), serum amyloid\u2010A (SAA), haptoglobin (Hp) and ceruloplasmin (Cp) concentrations in dogs with SM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Forty client\u2010owned dogs with SM (INF group) and 10 healthy control dogs (CON group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The INF group was divided into three subgroups; Group 1 (mild\/moderate), Group 2 (severe) and Group 3 (severe+pyoderma) according to the extent of skin lesions and the presence of concomitant pyoderma. Serum CRP, SAA, Hp and Cp concentrations of all study groups were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum CRP (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001), SAA (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001) and Hp (<jats:italic>P<\/jats:italic>\u00a0=\u20090.016) concentrations of the INF group were higher than the CON group, with no difference in terms of Cp. A statistical difference was measured between groups 2 and 1 in SAA only. C\u2010reactive protein was found to be significantly higher in dogs with severe SM accompanied by pyoderma (Group 3) when compared with dogs with severe SM (Group 2). The area under the receiver\u2010operating characteristic curves differentiating pyoderma among dogs with severe SM was 0.850 for CRP (<jats:italic>P<\/jats:italic>\u00a0=\u20090.0001, cut\u2010off value &gt;61.3\u2009mg\/L with sensitivity 69.29% and specificity 90.91%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The unique findings in this were that the SAA serum concentrations are related to the severity of SM and that serum CRP concentrations are effective in detecting the presence of pyoderma in dogs with severe SM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13095","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T13:39:19Z","timestamp":1654609159000},"page":"378-383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of the clinical severity of disease and concomitant pyoderma on serum acute\u2010phase proteins concentrations in dogs with sarcoptic mange"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0706-1856","authenticated-orcid":false,"given":"Ceren","family":"Dinler Ay","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Veterinary Faculty Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9729-8813","authenticated-orcid":false,"given":"Gulten Emek","family":"Tuna","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Veterinary Faculty Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9625-7956","authenticated-orcid":false,"given":"Gamze Sevri","family":"Ekren Asici","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Veterinary Faculty Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8399-7082","authenticated-orcid":false,"given":"Bulent","family":"Ulutas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Veterinary Faculty Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-3862.2012.00222.x"},{"key":"e_1_2_8_3_1","article-title":"Canine scabies: a zoonotic ectoparasitic skin disease","volume":"6","author":"Diwakar RP","year":"2017","journal-title":"Int J Curr Microbiol Appl Sci"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2014.10.024"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-015-4628-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2003.014563"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2016.07.013"},{"key":"e_1_2_8_8_1","unstructured":"WeeksENI KaufmanPE. 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