{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:07:08Z","timestamp":1747188428531,"version":"3.40.5"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment of <jats:italic>Malassezia pachydermatis<\/jats:italic> dermatitis can be performed by systemic or topical route. As <jats:italic>M.\u00a0pachydermatis<\/jats:italic> is located on the stratum corneum, topical therapy alone may be sufficient to resolve the infection. Owing to systemic antifungal resistance and adverse effects, topical treatment alone may improve treatment outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>To evaluate the efficacy of a topical spray composed of sodium benzoate, alcohol and botanical oils, compared to a shampoo containing 2% chlorhexidine gluconate and 2% miconazole nitrate for the treatment of <jats:italic>Malassezia pachydermaitis<\/jats:italic> dermatitis in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Sixteen client owned dogs diagnosed with symmetrical interdigital lesions as a result of secondary <jats:italic>Malassezia<\/jats:italic> dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study design was prospective, randomised and single\u2010blinded, using a split body protocol. <jats:italic>Malassezia<\/jats:italic> yeasts were determined by cytology at the inclusion day (day0) and after treatment (day14). All dogs were treated during 14\u2009days with both shampoo at one paw and spray on the other paw.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At day 14 a reduction of <jats:italic>Malassezia<\/jats:italic> dermatitis was shown at both paws. No statistical difference was demonstrated between treatment with shampoo or spray.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical importance<\/jats:title><jats:p>We could not show a difference in efficacy between application of the test spray once daily and the topical use of 2%miconazole\/2%chlorhexidine shampoo every other day. No adverse effects were reported.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13100","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T07:09:07Z","timestamp":1657523347000},"page":"398-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The efficacy of a novel topical spray composed of sodium benzoate, alcohol and botanical oils for the treatment of <i>Malassezia<\/i> dermatitis in dogs \u2013 a split body, randomised, blinded study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1575-0360","authenticated-orcid":false,"given":"Nicole P. M.","family":"Hoes","sequence":"first","affiliation":[{"name":"Dierendermatoloog Vroom  Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"van den Broek","sequence":"additional","affiliation":[{"name":"Department of Population Health University of Veterinary Sciences  CL Utrecht Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margreet W.","family":"Vroom","sequence":"additional","affiliation":[{"name":"Dierendermatoloog Vroom  Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"75","article-title":"Biology, diagnosis and treatment of Malassezia dermatitis in dogs and cats: Clinical consensus guidelines of the World Association for Veterinary Dermatology","volume":"31","author":"Bond R","year":"2020","journal-title":"Vet Dermatol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2008.00721.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2015.10.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2008.00675.x"},{"key":"e_1_2_8_6_1","unstructured":"Wet op dierproeven. 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