{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T07:39:15Z","timestamp":1764401955067,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Current treatments for sarcoptic mange in rabbits mainly include administration of avermectines every 10\u201330\u2009days. Recently, a single oral dose of fluralaner has been shown to be effective to treat sarcoptic mange in 12 pet rabbits over a three\u2010month period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To retrospectively assess the efficacy of a spot\u2010on combination of fluralaner plus moxidectin (Bravecto Plus) for the treatment of sarcoptic mange in rabbits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Ten client\u2010owned rabbits diagnosed with sarcoptic mange.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>An application of fluralaner plus moxidectin at an average dose of 25\u2009mg\/kg and 1.24\u2009mg\/kg, respectively, was administered topically once. Parasitological and dermatological examination was carried out weekly for one month and monthly for three months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age at diagnosis was 15 (range 3\u201348) months. Based on the age of onset, there were three juvenile (&lt;6\u2010month\u2010old) and seven adult\u2010onset cases. Of those, four were generalized (head, feet and\/or genital area) and six were localized form (head only). The combination of fluralaner plus moxidectin resulted in 100% eradication of mites and complete resolution of all skin lesions within 21\u2009days. Recurrence was not observed 90\u2009days post\u2010treatment. Relapse was not observed in one case followed up for a further four months and two rabbits followed up for a further six months. The other pets were lost to follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>These results indicated that a single dose of a formulation containing fluralaner plus moxidectin, at 25\u2009mg\/kg and 1.24\u2009mg\/kg, respectively, was effective for the treatment of naturally occurring sarcoptic mange in rabbits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13120","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T09:39:51Z","timestamp":1662370791000},"page":"3-6","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of a spot\u2010on combination of fluralaner plus moxidectin against naturally acquired <i>Sarcoptes scabiei<\/i> infestation in 10 pet rabbits: Retrospective case series"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6217-8571","authenticated-orcid":false,"given":"Dario","family":"d'Ovidio","sequence":"first","affiliation":[{"name":"Private practitioner  Arzano Italy"},{"name":"Anicura Clinica Veterinaria Malpensa  Samarate Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4893-4289","authenticated-orcid":false,"given":"Domenico","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12100"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-48435-0.00017-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2005.00446.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2007.00563.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvex.2013.05.011"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12363"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-020-04395-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/vrc2.109"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12429"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcam.2021.100528"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2010.01212.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-018-3175-z"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-48435-0.00012-5"},{"key":"e_1_2_7_15_1","first-page":"289","volume-title":"Skin diseases of exotic pets","author":"Meredith A","year":"2006"},{"key":"e_1_2_7_16_1","first-page":"281","article-title":"Efficacy of a formulation containing imidacloprid and moxidectin against naturally acquired ear mite infestations (Psoroptes cuniculi) in rabbits","volume":"3","author":"Hansen O","year":"2005","journal-title":"Intern J Appl Res Vet Med"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(00)00357-5"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12089"},{"key":"e_1_2_7_19_1","first-page":"65","article-title":"Corner diagnostico animali esotici","volume":"29","author":"d'Ovidio D","year":"2015","journal-title":"Riv ufficiale SCIVAC"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-018-3167-z"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-019-3512-x"},{"key":"e_1_2_7_22_1","unstructured":"EPAR. Available athttps:\/\/www.ema.europa.eu\/en\/documents\/assessment\u2010report\/bravecto\u2010plus\u2010epar\u2010public\u2010assessment\u2010report_en.pdf. Accessed Feb 4 2022."}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.13120","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vde.13120","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.13120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T09:53:13Z","timestamp":1692438793000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.13120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,5]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/vde.13120"],"URL":"https:\/\/doi.org\/10.1111\/vde.13120","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"type":"print","value":"0959-4493"},{"type":"electronic","value":"1365-3164"}],"subject":[],"published":{"date-parts":[[2022,9,5]]},"assertion":[{"value":"2022-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}