{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:43:41Z","timestamp":1789098221448,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009231","name":"European Society of Veterinary Dermatology","doi-asserted-by":"publisher","award":["Practitioners Research Grant 2018"],"award-info":[{"award-number":["Practitioners Research Grant 2018"]}],"id":[{"id":"10.13039\/501100009231","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Canine flank alopecia (CFA) is characterized by seasonally recurring noninflammatory, occasionally hyperpigmented alopecia predominantly in the thoracolumbar area. Previous studies suggest that reduced production of endogenous melatonin may play a role in the pathogenesis of this condition, and placebo\u2010controlled studies on the efficacy of preventative melatonin treatment are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of subcutaneous slow\u2010release melatonin implants in the prevention of CFA recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty\u2010one client\u2010owned dogs with a history of CFA were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>At time (T)0, a general physical and dermatological examination was performed on each dog, blood was collected for serum biochemistry analysis and two skin biopsies were taken from alopecic areas on the nonsedated affected dogs after subcutaneous injection with 2% lidocaine. Dogs with normal blood work and histological results compatible with CFA were included in the study. Participating dogs were randomly assigned to receive either placebo or 18\u2009mg melatonin subcutaneously in the interscapular area, approximately 2\u2009months before expected CFA onset (T1). CFA recurrence was scored qualitatively as complete, \u226450% recurrence, or no recurrence at 5 and 7\u2009months after the intervention (T2 and T3, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At T3, in dogs treated with placebo (nine of 17), the percentages for complete recurrence, \u226450% recurrence and no recurrence were 44%, 0% and 56%, respectively. In dogs treated with melatonin (eight of 17), these percentages were 25%, 50% and 25%, respectively. There were no statistically significant differences in the scores between melatonin\u2010treated dogs and placebo\u2010treated dogs (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.40). In three of eight melatonin\u2010treated dogs, mild transient swelling was observed at the injection site.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study did not provide evidence that an 18\u2009mg melatonin implant treatment, although well\u2010tolerated, is efficacious in preventing recurrence of CFA in affected dogs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13122","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T10:08:35Z","timestamp":1663236515000},"page":"553-558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The efficacy of subcutaneous slow\u2010release melatonin implants in the prevention of canine flank alopecia recurrence is uncertain: A double\u2010blind, randomized, placebo\u2010controlled study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1375-5424","authenticated-orcid":false,"given":"Millie U. M. Y.","family":"Verschuuren","sequence":"first","affiliation":[{"name":"Dierenartsen Combinatie ZuidOost Beek en Donk the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette M.","family":"Schlotter","sequence":"additional","affiliation":[{"name":"IDEXX B.V. Hoofddorp the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge M.","family":"van Geijlswijk","sequence":"additional","affiliation":[{"name":"Department Population Health Sciences, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaco J.","family":"van der Lugt","sequence":"additional","affiliation":[{"name":"IDEXX B.V. Hoofddorp the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronette","family":"Gehring","sequence":"additional","affiliation":[{"name":"Department Population Health Sciences, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"556","volume-title":"Muller and Kirk's small animal dermatology","author":"Miller WH","year":"2013"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.21825\/vdt.v83i6.16624"},{"key":"e_1_2_10_4_1","first-page":"155","volume-title":"Hair loss disorders in domestic animals","author":"Paradis M","year":"2009"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.22233\/9781905319886.13"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.2460\/javma.1993.203.11.1567","article-title":"Seasonal flank alopecia in boxers and Airdale terriers: 24 cases (1985\u20101992)","volume":"203","author":"Miller M","year":"1993","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2007.00512.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas1984.58157x"},{"key":"e_1_2_10_9_1","first-page":"546","volume-title":"Kirk's current veterinary therapy XIII","author":"Paradis M","year":"2000"},{"key":"e_1_2_10_10_1","volume-title":"Proceedings of the 11th AAVD\/ACVD meeting","author":"Paradis M","year":"1995"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-56053-626-0.50043-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1996.tb00251.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1051\/rnd:19800114"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470752487.ch20"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01049.x"},{"key":"e_1_2_10_16_1","unstructured":"Cimavet.Melovine [Internet]. Available from:https:\/\/cimavet.aemps.es\/cimavet\/pdfs\/es\/ft\/48+IP\/FT_48+IP.pdf[Accessed Jan 16 2022]."},{"key":"e_1_2_10_17_1","unstructured":"Drugs.com.Dermatonin [Internet]Available from:https:\/\/www.drugs.com\/vet\/dermatonin.html. 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