{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:57:21Z","timestamp":1782410241332,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Laser Doppler flowmetry (LDF) is a noninvasive method of measuring regional blood flow in humans. However, this method has not been widely applied to measure blood flow in dogs.<\/jats:p><\/jats:sec>Hypothesis\/Objectives<\/jats:title>We hypothesised that LDF can measure changes in blood flow in canine pinnae accurately. The objectives were to determine whether LDF could accurately detect dermal blood flow changes in canine pinnae caused by haemodynamic drugs and characterize the dermal blood flow in dogs with pinnal alopecia.<\/jats:p><\/jats:sec>Animals<\/jats:title>Sixteen laboratory\u2010owned healthy dogs, 25 client\u2010owned healthy control dogs and six dogs with pinnal alopecia suspected to be secondary to ischaemic dermatoses.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>Clinical doses of the haemodynamic drugs atropine, medetomidine and dibutyryl cyclic adenosine monophosphate (dBcAMP), as well as topical dBcAMP, were administered to healthy beagles. Subsequently, an LDF apparatus was attached to the pinnae to analyse changes in dermal blood flow. Finally, LDF was used to measure auricular dermal blood flow in dogs with pinnal alopecia compared to healthy dogs.<\/jats:p><\/jats:sec>Results<\/jats:title>Dermal blood flow increased after atropine injection, during dBcAMP infusion and after topical dBcAMP ointment application, and decreased after medetomidine injection. Auricular dermal blood flow (in mL\/min\/100\u2009g tissue) was significantly (p<\/jats:italic>\u2009<\u20090.05) lower in dogs with pinnal alopecia than in healthy dogs.<\/jats:p><\/jats:sec>Conclusions and Clinical Relevance<\/jats:title>Laser Doppler flowmetry is useful for measuring dermal blood flow in canine pinnae; it can be a noninvasive method to monitor ischaemic conditions of dog skin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13126","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T05:22:13Z","timestamp":1665724933000},"page":"70-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Validation of laser doppler flowmetry to measure dermal blood flow of the pinnae in dogs with pinnal alopecia"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6915-6562","authenticated-orcid":false,"given":"Kaori","family":"Ide","sequence":"first","affiliation":[{"name":"Tokyo University of Agriculture and Technology Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"Tokyo University of Agriculture and Technology Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Hiratsuka","sequence":"additional","affiliation":[{"name":"Tokyo University of Agriculture and Technology Fuchu Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiroh","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Tokyo University of Agriculture and Technology Fuchu Tokyo Japan"},{"name":"Pet Skin Clinic Kobe Hyogo 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