{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:51:05Z","timestamp":1767340265362,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T00:00:00Z","timestamp":1680393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The antitumour effects of interferon\u2010gamma (IFN\u2010\u03b3) in humans with cutaneous epitheliotropic T\u2010cell lymphoma (CETCL) have been described; however, the efficacy of IFN\u2010\u03b3 in dogs has not been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>The aim of this study was to evaluate the efficacy of recombinant canine IFN\u2010\u03b3 (rCaIFN\u2010\u03b3) therapy in dogs with CETCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty dogs with CETCL recruited from seven veterinary clinics were enrolled in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Fifteen dogs were treated with rCaIFN\u2010\u03b3, and five control dogs were treated with prednisolone. We evaluated survival time, skin lesions (erythema, nodules, ulcers and bleeding), pruritus and general condition (sleep, appetite and body weight). In the rCaIFN\u2010\u03b3 group, a questionnaire regarding the therapy was administered to owners after the dogs died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences existed in the median survival time between the rCaIFN\u2010\u03b3 and control groups (log\u2010rank test:<jats:italic>p<\/jats:italic>\u00a0=\u00a00.2761, Wilcoxon's rank sum test<jats:italic>: p<\/jats:italic>\u00a0=\u00a00.4444). However, there were significant differences in ulcer, bleeding, pruritus, sleep, appetite and body weight between the groups (Wilcoxon\u2013Mann\u2013Whitney U\u2010test:<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0023,<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0058,<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0005,<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0191,<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0306 and<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0306, respectively). Two (40%) of five dogs were euthanised in the control group, compared with none in the rCaIFN\u2010\u03b3 group. Fourteen questionnaires were collected, and owners reported that they were satisfied with the rCaIFN\u2010\u03b3 treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Although the median survival time was not prolonged, rCaIFN\u2010\u03b3 could be helpful in maintaining good quality of life for dogs with CETCL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13161","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T06:59:37Z","timestamp":1680505177000},"page":"460-467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical efficacy of recombinant canine interferon\u2010gamma therapy in dogs with cutaneous epitheliotropic T\u2010cell lymphoma"],"prefix":"10.1111","volume":"34","author":[{"given":"Tomoya","family":"Hoshino","sequence":"first","affiliation":[{"name":"Department of Dermatology Veterinary Specialists Emergency Centre Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Murayama","sequence":"additional","affiliation":[{"name":"Dermatology Services for Dogs and Cats Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Yamagishi","sequence":"additional","affiliation":[{"name":"Hongo Animal Hospital Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitoshi","family":"Okado","sequence":"additional","affiliation":[{"name":"Okado Animal Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruaki","family":"Iwai","sequence":"additional","affiliation":[{"name":"Iwai Animal Hospital Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Shirai","sequence":"additional","affiliation":[{"name":"Panda Animal Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soshi","family":"Hosaka","sequence":"additional","affiliation":[{"name":"Minamiosawa Animal Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter F.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology University of California Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0494-9710","authenticated-orcid":false,"given":"Masahiko","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Veterinary Specialists Emergency Centre Saitama Japan"},{"name":"Dermatology Services for Dogs and Cats Tokyo Japan"},{"name":"ASC Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2008.00176.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2018.08.007"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(94)90216-X"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00793.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-1-92"},{"key":"e_1_2_10_7_1","first-page":"421","article-title":"Canine cutaneous epitheliotropic lymphoma (mycosis fungoides) is a proliferative disorder of CD8+ T cells","volume":"144","author":"Moore PF","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_10_8_1","first-page":"754","article-title":"The behavior of epidermotropic lymphoma in twenty\u2010five dogs","volume":"30","author":"Wilcock BP","year":"1989","journal-title":"Can Vet J"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.240"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12752"},{"key":"e_1_2_10_11_1","first-page":"477","article-title":"Therapeutic management of cutaneous lymphoma in a dog","volume":"14","author":"Kshama MA","year":"2013","journal-title":"Intas Polivet"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2460\/javma.1993.202.03.387","article-title":"Use of isotretinoin and etretinate for the treatment of benign cutaneous neoplasia and cutaneous lymphoma in dogs","volume":"202","author":"White SD","year":"1993","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.1997.tb00262.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1111\/j.1939-1676.2006.tb00756.x","article-title":"Response of canine cutaneous epitheliotropic lymphoma to lomustine (CCNU): a retrospective study of 46 cases (1999\u20132004)","volume":"20","author":"Risbon RE","year":"2006","journal-title":"J Vet Intern Med"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-017-0978-7"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12976"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2015.05.008"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.29328\/journal.jhcr.1001001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00198"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.5326\/0440276"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-018-1710-y"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12086"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2006.00519.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12032"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2003.tb00127.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12611877"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-101-4-484"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12076"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.5.2391"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2417"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.12.021"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-6163.2003.tb00676.x"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.13161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T15:21:11Z","timestamp":1729178471000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.13161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,2]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/vde.13161"],"URL":"https:\/\/doi.org\/10.1111\/vde.13161","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"type":"print","value":"0959-4493"},{"type":"electronic","value":"1365-3164"}],"subject":[],"published":{"date-parts":[[2023,4,2]]},"assertion":[{"value":"2021-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}