{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:02:27Z","timestamp":1787911347072,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The high\u2010frequency ultrasonographic appearance of skin of dogs with atopic dermatitis (cAD) has not been described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare high\u2010frequency ultrasonographic findings among lesional, macroscopically nonlesional skin of dogs with cAD, and the macroscopically nonlesional skin of healthy dogs. Additionally, to determine whether there is any correlation between the ultrasonographic findings in lesional skin and local Canine Atopic Dermatitis Extent and Severity Index, 4th iteration (CADESI\u201004) or its domains (erythema, lichenification, excoriations\/alopecia). As a secondary aim, six cAD dogs were re\u2010evaluated after management intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty dogs with cAD (six were re\u2010examined after treatment) and six healthy dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In all dogs, ultrasonographic examination was performed on the same 10 skin sites, using a 50\u2009MHz transducer. Wrinkling of skin surface, presence\/width of subepidermal low echogenic band, hypoechogenicity of dermis and thickness of the skin were evaluated and scored\/measured blindly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dermal hypoechogenicity was more common and severe in lesional compared to macroscopically nonlesional skin of dogs with cAD. In lesional skin, presence\/severity of wrinkling of skin surface and of dermal hypoechogenicity were positively correlated with presence\/severity of lichenification, while severity of dermal hypoechogenicity was positively correlated with local CADESI\u201004. A positive correlation between the change in skin thickness and the change in the severity of erythema during treatment was noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>High\u2010frequency ultrasound biomicroscopy may be useful for the evaluation of skin of dogs with cAD and for evaluating the progression of skin lesions during treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13169","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T08:57:48Z","timestamp":1682672268000},"page":"415-424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High\u2010frequency ultrasound biomicroscopy findings of the skin of dogs with atopic 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