{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:36:40Z","timestamp":1790689000725,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T00:00:00Z","timestamp":1687651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dilute sodium hypochlorite (bleach) baths at 0.005% concentration twice weekly have been shown to markedly reduce the severity of atopic dermatitis in children, yet no tolerability and efficacy data are available for this treatment in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the local tolerability and the longitudinal effect on the density of <jats:italic>Staphylococcus pseudintermedius<\/jats:italic> of repeated diluted bleach baths on healthy dog skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Four healthy hound cross\u2010bred dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Bleach baths (0.005%; twice weekly for 15\u2009min) were applied to four healthy hound cross\u2010bred dogs over four weeks (eight baths). Local tolerability was assessed for axillae, abdomen and legs by an investigator before, immediately after and 24\u2009h after each bath. The longitudinal effect on density of <jats:italic>S.\u2009pseudintermedius<\/jats:italic> from axillae and groin was analysed through quantitative PCR before treatment [at Day (D)\u20107 and\u2009\u20103], during treatment on D4, D11 and D25, and on D30.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no erythema or scaling after the baths in any dog. Copy numbers of <jats:italic>S.\u2009pseudintermedius<\/jats:italic> in axillae, groin and both (axillae and groin together) were not significantly different at any time point during the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Repeated 0.005% hypochlorite bleach baths over four\u2009weeks were safe and well\u2010tolerated in healthy dogs without significant changes in the density of <jats:italic>S.\u2009pseudintermedius<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13186","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T04:30:20Z","timestamp":1687753820000},"page":"489-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tolerability and the effect on skin <i>Staphylococcus pseudintermedius<\/i> density of repeated diluted sodium hypochlorite (bleach) baths at 0.005% in healthy dogs"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4785-4121","authenticated-orcid":false,"given":"Frane","family":"Banovic","sequence":"first","affiliation":[{"name":"Department of Small Animal Medicine and Surgery College of Veterinary Medicine University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Reno","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery College of Veterinary Medicine University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9154-8909","authenticated-orcid":false,"given":"Sara D.","family":"Lawhon","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Pathobiology College of Veterinary Medicine and Biomedical Sciences Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Pathobiology College of Veterinary Medicine and Biomedical Sciences Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Rodrigues","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Pathobiology College of Veterinary Medicine and Biomedical Sciences Texas A&amp;M University  College Station Texas USA"},{"name":"Department of Comparative, Diagnostic and Population Medicine College of Veterinary Medicine University of Florida  Gainesville Florida 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Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.13186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T15:29:57Z","timestamp":1701271797000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.13186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,25]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/vde.13186"],"URL":"https:\/\/doi.org\/10.1111\/vde.13186","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,25]]},"assertion":[{"value":"2022-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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