{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:26:53Z","timestamp":1791473213066,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T00:00:00Z","timestamp":1690675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alopecia X in Pomeranians is caused by a hair cycle deregulation, associated with downregulation of key regulatory genes of the Wnt and Shh pathways, and stem\u2010cell markers. However, the pathogenesis remains unclear. p63 is an important transcription factor correlated with the aforementioned hair cycle modulating genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>The aim of this study was to highlight possible changes of p63 immunohistochemical expression within the hair follicles in canine alopecia X compared with normal skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Skin biopsies from 19 alopecia X\u2010affected and six control Pomeranians were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Serial histological sections of skin biopsies harbouring anagen, telogen and kenogen hair follicles were immunohistochemically evaluated for differences in p63 expression in the affected and control samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dogs with alopecia X had a significantly decreased immunoexpression of p63 in telogen and kenogen hair follicles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>The decrease of p63 immunoexpression observed in canine alopecia X suggests an involvement of p63 in hair cycle.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13195","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T04:40:11Z","timestamp":1690778411000},"page":"567-575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>p63<\/scp> immunoexpression in hair follicles of normal and alopecia X\u2010affected skin of Pomeranian dogs"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6796-8206","authenticated-orcid":false,"given":"Leonardo","family":"Della\u00a0Salda","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine University of Teramo  Teramo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bongiovanni","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Teramo  Teramo Italy"},{"name":"Department of Biomolecular Sciences, Faculty of Veterinary Medicine Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7204-6495","authenticated-orcid":false,"given":"Marcella","family":"Massimini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Teramo  Teramo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5066-0811","authenticated-orcid":false,"given":"Mariarita","family":"Romanucci","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Teramo  Teramo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Vercelli","sequence":"additional","affiliation":[{"name":"Veterinary Clinic and Analysis Laboratory \u2018Citt\u00e0 di Torino\u2019  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Colosimo","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Agro\u2010Food and Environmental Technology University of Teramo  Teramo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona","family":"Di\u00a0Matteo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Teramo  Teramo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Vanessa Patrizia","family":"Defourny","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise\"G. 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