{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:10:37Z","timestamp":1774926637533,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007841","name":"Council of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007841","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Footbaths can be used to manage digital dermatitis (DD), a common cause of lameness in dairy cattle. Copper sulfate and chelated copper\u2013zinc (CZS) solutions in footbaths are potentially harmful to the environment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>To determine if a quaternary ammonium salt\u2010based disinfectant (QASD) footbath is as effective as a chelated CZS solution in controlling DD in dairy cows.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Fifty\u2010one lactating Holstein cows were randomly assigned to one of two treatment groups, with DD status based on the M\u2010stage scoring system and locomotion score balanced between treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The groups were treated with a 1% QASD or a 2.5% chelated CZS. Footbaths were performed once per week for 15\u2009weeks. Logistic regression was used to analyse clinical improvement. All cows received appropriate medical treatment for DD and other hoof diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical improvement rates were 67% in the QASD group and 38% in the CZS group (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). Logistic regression analysis showed that the odds (95% confidence interval) for clinical improvement rate in the CZS group were 0.30 (0.095\u20130.948) times that of the QASD group (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). The M0 score in the QASD and CZS groups increased significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) at the end of the 15\u2009week study period. In the QASD group, the proportion of M2, M3 and M4 scores were significantly decreased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Clinical Relevance<\/jats:title><jats:p>Over a 15\u2009week period, QASD for footbathing was associated with a lower prevalence of active DD lesions than when using CZS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13202","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T06:46:38Z","timestamp":1694587598000},"page":"608-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of quaternary ammonium salt\u2010based disinfectant or chelated copper\u2013zinc footbath solution in the treatment of digital dermatitis on one research dairy farm in Taiwan"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5073-0085","authenticated-orcid":false,"given":"Yi\u2010Hsuan","family":"Chen","sequence":"first","affiliation":[{"name":"Taipei Zoo  Taipei Taiwan"},{"name":"Department of Animal Science and Technology National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Miaoli Animal Care and Health Office  Miaoli City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3141-7672","authenticated-orcid":false,"given":"Po\u2010An","family":"Tu","sequence":"additional","affiliation":[{"name":"Hsinchu Branch, Livestock Research Institute Council of Agriculture  Miaoli Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Hsin","family":"Yeh","sequence":"additional","affiliation":[{"name":"Hsinchu Branch, Livestock Research Institute Council of Agriculture  Miaoli Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo\u2010Hua","family":"Lee","sequence":"additional","affiliation":[{"name":"Hsinchu Branch, Livestock Research Institute Council of Agriculture  Miaoli Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7701-3163","authenticated-orcid":false,"given":"Jih\u2010Tay","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Technology National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2021.2907-2912"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/inp.m4454"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2019.105417"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2008-1135"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2010.03.001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2016-11365"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.06.054"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2004.08.009"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.162.2.41"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2010-3246"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2011-4983"},{"key":"e_1_2_9_13_1","unstructured":"Plomp.Practical trial: Intra\u2010bath concept. 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