{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:07:27Z","timestamp":1747188447477,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intradermal (IDT) and prick (PT) tests are used to select allergens for allergen\u2010specific immunotherapy in dogs with atopic dermatitis (cAD). However, the use of antipruritic drugs before performing these tests may influence the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the influence of the drugs oclacitinib and prednisolone on the immediate\u2010phase reactions of IDT and PT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal<jats:bold>s<\/jats:bold><\/jats:title><jats:p>Thirty client\u2010owned dogs with cAD with positive reactions to at least one allergen extract on IDT or PT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Dogs were randomly assigned to receive oclacitinib 0.4\u20130.58\u2009mg\/kg per os, every 12\u2009h (<jats:italic>n<\/jats:italic>\u2009=\u200914), or prednisolone 0.37\u20130.65\u2009mg\/kg p.o., every 12\u2009h (<jats:italic>n<\/jats:italic>\u2009=\u200916) for 14\u2009days. IDT and PT were performed on Day (D)0 before treatment and on D14.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At D14 there was no significant reduction in the means of the orthogonal diameters of the positive immediate\u2010phase reactions of the IDT (<jats:italic>p<\/jats:italic>\u2009=\u20090.064) in the oclacitinib group; however, in the PT, the diameter of the positive reactions reduced significantly (<jats:italic>p<\/jats:italic>\u2009=\u20090.048). In both tests, there was no significant reduction in the total number of positive reactions (IDT, <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.999; PT, <jats:italic>p<\/jats:italic>\u2009=\u20090.735). In the prednisolone group, the means of the orthogonal diameters of positive immediate\u2010phase reactions were significantly reduced in both tests (IDT, <jats:italic>p<\/jats:italic>\u2009=\u20090.001; PT, <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.001) and there also was a reduction in the total number of positive reactions (IDT, <jats:italic>p<\/jats:italic>\u2009=\u20090.022; PT, <jats:italic>p<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>The use of oclacitinib 0.4\u20130.58\u2009mg\/kg twice daily for 14\u2009days does not interfere with IDT results in dogs with cAD. However, oclacitinib may reduce PT reactivity. The use of prednisolone 0.37\u20130.65\u2009mg\/kg twice daily results in a reduction in both IDT and PT results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13209","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T02:40:53Z","timestamp":1695955253000},"page":"71-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A randomised, double\u2010blinded trial to assess the effect of oclacitinib and prednisolone on intradermal allergen and prick tests in dogs with atopic dermatitis"],"prefix":"10.1111","volume":"35","author":[{"given":"Let\u00edcia Talita","family":"Baretta","sequence":"first","affiliation":[{"name":"Faculdade de Veterin\u00e1ria Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"do Esp\u00edrito\u00a0Santo\u00a0Cunha","sequence":"additional","affiliation":[{"name":"Veterinary 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