{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:24:09Z","timestamp":1787016249636,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary cutaneous lymphoma represents 0.2%\u20133% of all feline lymphomas, with nonepitheliotropic lymphomas being the most common. In humans and dogs, subcutaneous panniculitis\u2010like T\u2010cell lymphoma (SPTCL) is a primary nonepitheliotropic lymphoma with a T\u2010cell phenotype developing in the subcutis and often mimicking inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this report is to describe pathological, phenotypical and clonal features of SPTCL in cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Six cats with SPTCL were included in this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Skin biopsies were formalin\u2010fixed, routinely processed and stained. Histological and immunohistochemical investigation for anti\u2010CD18, CD204, CD79a, CD20, CD3, FeLVp27and FeLVgp70 and clonality assessment were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four male and two female domestic shorthair cats, mean age 11.2\u2009years, developed SPTCL in the abdominal (three), inguinal (two) and thoracic (one) regions. Variably pleomorphic neoplastic lymphoid cells were present in the panniculus in percentages, expanding the septa (six of six) and extending into fat lobules in one of six cats. Tumours were associated with elevated numbers of neutrophils (five of six), lesser macrophages (six of six) and variable necrosis (six of six). Neoplastic cells expressed CD3\n                      <jats:sup>+<\/jats:sup>\n                      (six of six), with clonal T\u2010cell receptor rearrangement detected in five of six cats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>This is the first description of SPTCL in cats. Lesions can be confused with panniculitis, leading to delay in diagnosis and therapy. Awareness of this neoplastic disease is relevant to avoid misdiagnoses and to gain greater knowledge about the disease in cats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.13211","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T03:10:11Z","timestamp":1698721811000},"page":"207-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Subcutaneous panniculitis\u2010like T\u2010cell lymphoma: Morphological, immunophenotypical and clonality assessment in six cats"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3672-4612","authenticated-orcid":false,"given":"Paola","family":"Roccabianca","sequence":"first","affiliation":[{"name":"DIVAS, Universit\u00e0 Degli Studi di Milano  Lodi (LO), Lombardia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Dell'Aere","sequence":"additional","affiliation":[{"name":"DIVAS, Universit\u00e0 Degli Studi di Milano  Lodi (LO), Lombardia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Avallone","sequence":"additional","affiliation":[{"name":"DIMEVET Universit\u00e0 Degli Studi di Bologna  Grugliasco (BO), Emilia Romagna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa","family":"Zamboni","sequence":"additional","affiliation":[{"name":"DIVAS, Universit\u00e0 Degli Studi di Milano  Lodi (LO), Lombardia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Bertazzolo","sequence":"additional","affiliation":[{"name":"Laboratorio Mylav  Rho (MI), Lombardia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Crippa","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery University of Milano\u2010Bicocca  Monza (MB), Lombardia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Giudice","sequence":"additional","affiliation":[{"name":"DIVAS, Universit\u00e0 Degli Studi di Milano  Lodi (LO), Lombardia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Caniatti","sequence":"additional","affiliation":[{"name":"DIVAS, Universit\u00e0 Degli Studi di Milano  Lodi (LO), Lombardia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1118-9016","authenticated-orcid":false,"given":"Verena K.","family":"Affolter","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, Immunology University of California Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"383","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Jaffe ES","year":"2017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119485933.ch6"},{"key":"e_1_2_9_4_1","first-page":"203","volume-title":"Tumors in domestic animals","author":"Valli VE","year":"2017"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004562"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018028340"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-087288"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.5858\/133.2.303"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-881268"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810379428"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985818789474"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/9780470752487.ch37","volume-title":"Skin diseases of the dog and cat, clinical and histopathologic diagnosis","author":"Gross TL","year":"2005"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(94)90216-X"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2011.00972.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2004.00352.x"},{"key":"e_1_2_9_17_1","first-page":"1","article-title":"Multifocal cutaneous non\u2010epitheliotropic B\u2010cell lymphoma in a cat","volume":"6","author":"Quintavalla F","year":"2020","journal-title":"JFMS Open Rep"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.1998.0267"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985815623620"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1309\/BFH5-NCNP-DK3J-DQBH"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985815593349"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985821999831"},{"key":"e_1_2_9_23_1","article-title":"Mitotic count guideline, version 1.0","author":"Meuten DJ","year":"2021","journal-title":"Veterinary Cancer Guidelines and Protocols"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813478210"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638717704239"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.43-5-646"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063879700900120"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.150.12.5429"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.42.11.1194"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10060280"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2005.02.014"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16288"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.42-5-596"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12767"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000030233"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/106.1.78"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02458"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638718794765"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.149.6.1876"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985815595518"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470376928.ch3"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2010.02.014"},{"key":"e_1_2_9_43_1","first-page":"199","article-title":"Immunohistochemical identification of B and T lymphocytes in formalin\u2010fixed, paraffin\u2010embedded feline lymphosarcomas: relation to feline leukemia virus status, tumor site, and patient age","volume":"60","author":"Jackson ML","year":"1996","journal-title":"Can J Vet Res"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2005.00480.x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1809624"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012980"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.650822"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/824528"},{"key":"e_1_2_9_49_1","first-page":"110","article-title":"Diagnosis and treatment of subcutaneous panniculitis\u2010like T\u2010cell lymphoma: a systematic literature review","volume":"16","author":"Alsomali DY","year":"2023","journal-title":"Hematol Oncol Stem Cell Ther"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.13211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T21:10:09Z","timestamp":1709500209000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.13211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,31]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/vde.13211"],"URL":"https:\/\/doi.org\/10.1111\/vde.13211","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,31]]},"assertion":[{"value":"2022-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}