{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:07:32Z","timestamp":1747188452376,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009231","name":"European Society of Veterinary Dermatology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009231","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Diascopy is a point\u2010of\u2010care diagnostic test used to differentiate skin erythema due to vascular dilation from haemorrhage. In the veterinary literature, only a handful of diseases have been described to be associated with a negative (nonblanching) diascopy result, and histological investigation of haemorrhage has been inconsistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Retrospective study to undertake a histopathological investigation of canine, nonblanching erythematous dermatoses for the presence or absence of haemorrhage and vascular changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Skin biopsies from dogs presented with moderate\u2010to\u2010severe nonblanching erythema were evaluated histologically. Additionally, clinical data about each patient were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty cases were identified with nonblanching erythema. Diagnoses included vasculopathy (<jats:italic>n<\/jats:italic>\u2009=\u20096), canine eosinophilic dermatitis (<jats:italic>n<\/jats:italic>\u2009=\u20093), cutaneous epitheliotropic T\u2010cell lymphoma (<jats:italic>n<\/jats:italic>\u2009=\u20092), and one case each of sterile granuloma and pyogranuloma syndrome, German shepherd dog pyoderma, multiple mast cell tumours, haemangiosarcoma, exfoliative cutaneous lupus erythematosus, canine leishmaniosis with sebaceous adenitis, sebaceous adenitis with concurrent dermatophytosis, calcinosis cutis and canine atopic dermatitis with insect\u2010bite reaction. One or more vascular changes were present in all 20 cases and included perivascular oedema, endothelial swelling and neutrophilic infiltration of vessel walls. Haemorrhage was identified in 17 of 20 cases (85%). Three cases without dermal haemorrhage were calcinosis cutis, sebaceous adenitis with dermatophytosis and canine atopic dermatitis with insect\u2010bite reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Negative diascopy was associated with haemorrhage and vascular pathological findings in the majority of cases, yet not all. Haemorrhage was identified histologically in all diseases previously reported as nonblanching as well as in a few additional diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13230","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T08:57:13Z","timestamp":1702976233000},"page":"255-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diascopy and histopathological evaluation of nonblanching erythematous dermatoses in dogs"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3147-6574","authenticated-orcid":false,"given":"Stephanie","family":"Forbes","sequence":"first","affiliation":[{"name":"AniCura Tier\u00e4rztliche Spezialisten Hamburg  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonya","family":"Bettenay","sequence":"additional","affiliation":[{"name":"Centre for Clinical Veterinary Medicine University 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