{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:13:23Z","timestamp":1792181603194,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Supplementation of polyunsaturated fatty acids (PUFA) enables dose reduction of prednisolone and ciclosporin in canine atopic dermatitis (cAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine if oral administration of PUFA reduces the dose of oclacitinib in cAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty\u2010two client\u2010owned dogs with cAD receiving oclacitinib.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Dogs received a fish oil product (PUFA) or paraffin oil (placebo) for 16\u2009weeks. Owners adjusted the oclacitinib dose according to daily pruritus assessments. On Day (D)0, D56 and D112, Canine Atopic Dermatitis Extent and Severity Index, fourth iteration (CADESI\u201004), pruritus Visual Analog Scale (PVAS), quality\u2010of\u2010life score (QoL), Global Assessment (GA), quality\u2010of\u2010coat (QoC) and adverse events were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean daily oclacitinib dose was significantly reduced in the PUFA group from 0.51\u2009\u00b1\u20090.20\u2009mg\/kg\/24\u2009h (D0) to 0.19\u2009\u00b1\u20090.14\u2009mg\/kg\/24\u2009h (D85\u2013112; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001) and not in the placebo group (D0: 0.70\u2009\u00b1\u20090.33\u2009mg\/kg\/24\u2009h; D85\u2013112: 0.53\u2009\u00b1\u20090.35\u2009mg\/kg\/24\u2009h, <jats:italic>p<\/jats:italic>\u2009=\u20090.5422). CADESI\u201004 did not change over time or differ between groups. PVAS was significantly lower in the PUFA group (2.8\u2009\u00b1\u20091.5) compared to placebo (4.2\u2009\u00b1\u20091.6) at D112 (<jats:italic>p<\/jats:italic>\u2009=\u20090.0375). QoL and QoC improved only in the PUFA group (QoL: D0: 20\u2009\u00b1\u20097, D112: 12\u2009\u00b1\u20095, <jats:italic>p<\/jats:italic>\u2009=\u20090.0057; QoC: D0: 0\u2009\u00b1\u20090.5, D112: 1\u2009\u00b1\u20090.5, <jats:italic>p<\/jats:italic>\u2009=\u20090.0410). GA on D112 was higher in the PUFA group (<jats:italic>p<\/jats:italic>\u2009=\u20090.008). No adverse events were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oral supplementation of PUFA allowed dose reduction of oclacitinib and improved PVAS, QoL, QoC and GA. The use of PUFA is recommended and was safe in the atopic study dogs receiving oclacitinib.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13246","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T09:30:19Z","timestamp":1710149419000},"page":"408-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A placebo\u2010controlled, double\u2010blind study evaluating the effect of orally administered polyunsaturated fatty acids on the oclacitinib dose for atopic dogs"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8713-4065","authenticated-orcid":false,"given":"Laura","family":"Sch\u00e4fer","sequence":"first","affiliation":[{"name":"Clinic for Small Animals, Internal Medicine Justus\u2010Liebig\u2010University Giessen  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Thom","sequence":"additional","affiliation":[{"name":"Clinic for Small Animals, Internal Medicine Justus\u2010Liebig\u2010University Giessen  Giessen Germany"},{"name":"Small Animal Practice \u2018Am Aartalsee\u2019  Hohenahr Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(01)00296-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxy015"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.435"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.252"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.2020.1758357"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1767"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.38-6-720"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00802.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2011.00967.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2010.00954.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2011.00956.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01306.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)34214-0"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/JAN.2018.6"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-018-1845-5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.1994.tb00028.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00860.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/63.1.116"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(85)90009-8"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2015.11.012"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2004.00378.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1995.tb02961.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.134.2.30"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.1991.tb00105.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(01)00316-6"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-015-0514-6"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12047"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13193"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00758.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-015-0515-5"},{"issue":"77","key":"e_1_2_9_32_1","article-title":"International committee on allergic diseases of animals (ICADA). 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