{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:11:22Z","timestamp":1792181482142,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While alopecia associated with hair cycle arrest (HCA, Alopecia X) is well\u2010recognised in Pomeranian dogs, the authors are unaware of reports of concurrent hair fragility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Following the observation of frequent hair shaft abnormalities in alopecic Pomeranians, we hypothesised that hair fragility events would be more frequent in dogs with a phenotype of HCA when compared to dogs with normal coats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Eight alopecic Pomeranian dogs or crosses with a phenotype of HCA and 36 unaffected Pomeranians with owner\u2010reported normal hair coats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>All affected dogs underwent dermatological examination and clinicopathological evaluations. Hair samples, plucked from affected areas or obtained by brushing from unaffected dogs, were examined microscopically for structural abnormalities. Hair fragility events were characterised as trichorrhexis nodosa (TN) or longitudinal splits and were expressed per 10\u2009mg of hair. A reference interval was calculated from the number of hair fragility events in the samples from unaffected dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The upper reference limit (with 90% confidence) from samples of 35 unaffected Pomeranians (one outlier excluded) was 9.75 hair fragility events per 10\u2009mg of hair. The median (range) of fragility events in eight dogs with a phenotype of HCA was 66.0 (30.2\u2013166.7) per 10\u2009mg of hair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>Clinicians should routinely perform trichography in Pomeranians with HCA because abundant hair abnormalities, particularly TN, may contribute to poor hair coat quality. Further studies are required to establish the pathophysiology of and treatments for these fragility events and to determine their predictive value for HCA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.13296","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T07:00:10Z","timestamp":1727679610000},"page":"64-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hair fragility (trichorrhexis nodosa) in alopecic Pomeranian dogs"],"prefix":"10.1111","volume":"36","author":[{"given":"Erin","family":"Brennan","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Services Royal Veterinary College  Hatfield Herts UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonna","family":"Juhola","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Services Royal Veterinary College  Hatfield Herts UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewan A.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Services Royal Veterinary College  Hatfield Herts UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0446-3729","authenticated-orcid":false,"given":"Anette","family":"Loeffler","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Services Royal Veterinary College  Hatfield Herts UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8833-7836","authenticated-orcid":false,"given":"Rosario","family":"Cerundolo","sequence":"additional","affiliation":[{"name":"Bayswater Referral Clinic  Bayswater, London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Hendricks","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Services Royal Veterinary College  Hatfield Herts UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2222-9589","authenticated-orcid":false,"given":"Ross","family":"Bond","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Services Royal Veterinary College  Hatfield Herts UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"573","volume-title":"Muller and Kirk's small animal dermatology","author":"Miller WH","year":"2013"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-74612-3_15"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-46911-7_14"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2000.00180.x"},{"key":"e_1_2_10_6_1","first-page":"736","volume-title":"Muller and Kirk's small animal dermatology","author":"Scott DW","year":"1995"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0212645"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12605"},{"key":"e_1_2_10_9_1","first-page":"467","article-title":"Hyposomatotropism in the mature dog: a discussion of 22 cases","volume":"22","author":"Scott DW","year":"1986","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_10_10_1","first-page":"824","article-title":"Growth hormone responsive alopecia in the mature dog: a discussion of 13 cases","volume":"16","author":"Parker WM","year":"1980","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_10_11_1","first-page":"23","volume-title":"Endocrine diseases of the dog","author":"Siegel ET","year":"1977"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1990.197.10.1333"},{"key":"e_1_2_10_13_1","first-page":"451","volume-title":"Advances in veterinary dermatology, volume 2","author":"Schmeitzel LP","year":"1992"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470752487.ch16"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.226.1494"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13114"},{"key":"e_1_2_10_17_1","unstructured":"Anonymous.Black Skin Disease (BSD)\/Alopecia X (loss of hair). [cited 2023 Dec 01]. Available from:https:\/\/thepomeranianclubuk.weebly.com\/black\u2010skin\u2010disease\u2010bsd\u2010\u2010alopecia\u2010x\u2010loss\u2010of\u2010hair.html"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186469"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12006"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/46.6.867"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2003.00330.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2004.00403.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.236.11.1208"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/03009858231170295"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01049.x"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.13296","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vde.13296","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.13296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:22:00Z","timestamp":1772968920000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.13296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/vde.13296"],"URL":"https:\/\/doi.org\/10.1111\/vde.13296","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,30]]},"assertion":[{"value":"2023-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}