{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:28:12Z","timestamp":1788298092754,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intradermal allergen testing (IDAT) is commonly used to formulate allergen\u2010specific immunotherapy, a pillar treatment for canine atopic dermatitis. Many sedatives have shown histaminergic or anti\u2010histaminergic effects and thus been deemed unsuitable for IDAT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The goal of this study was to determine whether, in healthy dogs, dexmedetomidine (Dexdomitor) or a 1:20 combination of medetomidine and vatinoxan (Zenalpha) will affect intradermal reactions compared to unsedated dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Ten privately owned healthy dogs were enrolled in this equivalence study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Wheal formation was subjectively and objectively assessed in conscious then sedated dogs. Dogs were randomly sedated with either Dexdomitor (dexmedetomidine [0.5\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ]) or Zenalpha (medetomidine [1\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      \/vatinoxan] 20\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) intramuscularly. Once sedated, five 10\u2010fold histamine (100\u20130.01\u2009\u03bcg\/mL) and compound 48\/80 (200\u20130.02\u2009\u03bcg\/mL) dilutions were intradermally injected into the lateral thorax. The study was repeated on the opposite side with the alternative sedation 1\u2009week later. Quality of sedation, cardiorespiratory function and rectal temperature were recorded every 5\u2009min.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no difference in the median values of the reactions with either sedative when compared to unsedated dogs. Dexdomitor and Zenalpha achieved an equivalence in both subjective and objective scoring systems for all concentrations tested. A faster median time to sedation (10 vs. 18\u2009min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013) was seen with Zenalpha compared to Dexdomitor. Although both sedatives depressed the cardiovascular function, such parameters were less affected by Zenalpha than by Dexdomitor (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>Owing to the lack of effects on wheal formation, both sedatives are appropriate for sedating dogs undergoing IDAT. Although, such results should be validated in allergic dogs. Zenalpha may induce more rapid and reliable sedation than Dexdomitor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.13306","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T04:19:00Z","timestamp":1728879540000},"page":"43-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Equivalence in intradermal reactions to histamine and compound 48\/80 in dogs before and after sedation with dexmedetomidine or a 1:20 combination of medetomidine and vatinoxan"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4893-4289","authenticated-orcid":false,"given":"Domenico","family":"Santoro","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raiane A.","family":"Moura","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart R.","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Department of Comparative, Diagnostic and Population Medicine College of Veterinary Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Chiavaccini","sequence":"additional","affiliation":[{"name":"Department of Comparative, Diagnostic and Population Medicine College of Veterinary Medicine University of Florida  Gainesville Florida 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