{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:22:25Z","timestamp":1791595345972,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Janus kinase inhibitors (JAKi) have been shown to reduce pruritus and improve associated inflammatory skin lesions in canine atopic dermatitis (cAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy and safety of ilunocitinib, in comparison to oclacitinib, for the control of cAD in a randomised, blinded trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Three\u2010hundred\u2010and\u2010thirty\u2010eight dogs with cAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Dogs were randomised to receive oclacitinib (0.4\u20130.6\u2009mg\/kg twice daily for 14\u2009days; then once daily) or ilunocitinib (0.6\u20130.8\u2009mg\/kg once daily), for up to 112\u2009days. Owners assessed pruritus using an enhanced Visual Analog Scale (PVAS). Investigators assessed skin lesions using the Canine Atopic Dermatitis Extent and Severity Index, 4th interaction (CADESI\u201004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Reduction in pruritus and CADESI\u201004 scores was similar for both treatment groups from Day (D)0\u2013D14. PVAS scores increased between D14 and D28 for oclacitinib and decreased for ilunocitinib. On D28 to D112, mean PVAS and CADESI\u201004 scores were significantly lower for ilunocitinib compared to oclacitinib (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.003 and <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.023, respectively). On D28 to D112, a greater number of ilunocitinib\u2010treated dogs achieved clinical remission of pruritus (i.e. PVAS score\u2009&lt;2). Subjective assessment of overall response was significantly better for ilunocitinib on D28 to D112 (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.002). Both drugs demonstrated similar safety throughout the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Ilunocitinib rapidly and safely controlled signs of cAD. Ilunocitinib demonstrated significantly better control of pruritus and skin lesions compared to oclacitinib, with more dogs achieving clinical remission of pruritus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13319","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T09:29:54Z","timestamp":1736155794000},"page":"165-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparative efficacy and safety of ilunocitinib and oclacitinib for the control of pruritus and associated skin lesions in dogs with atopic dermatitis"],"prefix":"10.1111","volume":"36","author":[{"given":"Sophie","family":"Forster","sequence":"first","affiliation":[{"name":"Elanco Animal Health Ltd  Hook UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Boegel","sequence":"additional","affiliation":[{"name":"Elanco Animal Health GmbH  Leverkusen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Despa","sequence":"additional","affiliation":[{"name":"Elanco Animal Health  Greenfield Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace","family":"Trout","sequence":"additional","affiliation":[{"name":"Elanco Animal Health  Greenfield Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"King","sequence":"additional","affiliation":[{"name":"Elanco Animal Health  Greenfield Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14791"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01098.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.12.994"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12500"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12762"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12088"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12186"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12166"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13134"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.11.020"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01094.x"},{"issue":"1","key":"e_1_2_10_13_1","first-page":"2","article-title":"Oclacitinib for the treatment of pruritus and lesions associated with canine flea allergic dermatitis","volume":"23","author":"Wheeler D","year":"2012","journal-title":"Vet Dermatol"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01088.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2002.221.370"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-018-1569-y"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-023-00735-0"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2007.00616.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12107"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-015-0515-5"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00758.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-223850"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2010.00899.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12194"},{"key":"e_1_2_10_25_1","unstructured":"CVMP assessment report for APOQUEL (EMEA\/V\/C\/002688\/0000). 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