{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:01:55Z","timestamp":1783728115957,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic and recurrent pyoderma in dogs is driving a growing interest in natural antimicrobial products that offer minimal adverse effects and avoid antibiotic resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Evaluate the safety and efficacy of dermatological products with antimicrobial peptides and plant extracts, comparing them to chlorhexidine + miconazole and cephalexin therapy for superficial pyoderma in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Forty\u2010five dogs with superficial pyoderma underwent clinical, cytopathological and microbiological diagnosis, and were randomly assigned to Group 1 (G1) treated with shampoo (two weekly baths) and lotion (twice daily on the affected areas) containing natural antimicrobials; Group 2 (G2) treated with two weekly baths using a therapeutic shampoo containing 2% chlorhexidine and 2.5% miconazole; or Group 3 (G3) treated with oral cephalexin 30\u2009mg\/kg twice daily. <jats:italic>Staphylococcus<\/jats:italic> spp. strains were identified using matrix\u2010assisted laser desorption ionisation\u2013time of flight mass spectrometry and pruritus Visual Analog Scale (PVAS)\/lesion scores were evaluated on Day (D)0, D7, D14, D21 and D28.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Statistical differences (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) were noted between D0 and D28 in PVAS values and lesion scores for all groups. G1 had lower PVAS scores than other groups on D7 and D14 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and lower lesion scores than G3 on D7. By D28, G1 and G3 had lower lesion scores than G2. Notably, G1 and G2 had no adverse effects, while 26% of G3 patients experienced gastrointestinal issues during therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>This preliminary investigation of the new product (G1) suggests that it is effective, safe and a promising topical treatment for managing superficial pyoderma in dogs, offering an alternative to systemic antibiotics and topical antiseptic treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13323","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T05:40:01Z","timestamp":1736401201000},"page":"137-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative study of a commercial formula containing natural antimicrobials versus oral cephalexin or topical chlorhexidine\u2010miconazole therapies for treating superficial pyoderma in dogs"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9102-1066","authenticated-orcid":false,"given":"Vanessa Cunningham","family":"Gmyterco","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, School of Medicine and Life Sciences Pontif\u00edcia Universidade Cat\u00f3lica Do Paran\u00e1  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0816-2111","authenticated-orcid":false,"given":"Fernando Bittencourt","family":"Luciano","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, School of Medicine and Life Sciences Pontif\u00edcia Universidade Cat\u00f3lica Do Paran\u00e1  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0004-9990","authenticated-orcid":false,"given":"Lucas Andr\u00e9","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of 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