{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:24:14Z","timestamp":1787016254922,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Canine atopic dermatitis (cAD) is a chronic inflammatory and pruritic dermatopathy requiring a multimodal therapeutic approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the effectiveness, safety and cost of oclacitinib and prednisolone treatment in dogs with AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty\u2010three client\u2010owned dogs with cAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Dogs were randomly assigned to one of two groups: Group 1 received prednisolone (0.5\u2009mg\/kg every 24\u2009h) for 7\u2009days, then oclacitinib (0.5\u2009mg\/kg) and prednisolone (0.5\u2009mg\/kg), were administered alternately with a 1\u2009day pause between each drug, for 7 additional weeks. Group 2 received oclacitinib (0.5\u2009mg\/kg every 12\u2009h for 14\u2009days, then every 24\u2009h) for 8\u2009weeks. Assessments included the Canine Atopic Dermatitis Extent and Severity Index, 4th iteration (CADESI\u201004) and pruritus Visual Analog Scale (PVAS) on Day (D)0, D7, D14, D30, D45 and D60.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both groups showed significant CADESI and PVAS reductions on D7 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). From D14 to D60, mean scores remained stable compared to D7, with no significant differences between groups. Adverse events included two dogs with polyuria and polydipsia, and three with polyphagia in Group 1, all of which resolved by D14. In Group 2, one dog experienced polyphagia, and two had self\u2010limiting vomiting. Three dogs in Group 1 and one dog in Group 2 had mild increases in liver enzyme concentrations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>The combined protocol was effective and safe for managing itch and inflammation over a 60\u2009day period. It had a 73.3% lower cost compared to oclacitinib alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.13327","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T04:50:11Z","timestamp":1738558211000},"page":"177-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of oclacitinib maleate and prednisolone combined therapy for the control of atopic dermatitis in dogs: A controlled clinical trial"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5792-5736","authenticated-orcid":false,"given":"T\u00e1ssia Sell","family":"Ferreira","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, School of Medicine and Life Sciences Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5782-7971","authenticated-orcid":false,"given":"Wendy Rold\u00e1n","family":"Villalobos","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, School of Medicine and Life Sciences Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9102-1066","authenticated-orcid":false,"given":"Vanessa Cunningham","family":"Gmyterco","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, School of Medicine and Life Sciences Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3904-839X","authenticated-orcid":false,"given":"Diogo Sim\u00f5es","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Graduate Program in Rehabilitation Sciences and Physical\u2010Functional Performance, Faculty of Physiotherapy Universidade Federal de Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4428-1767","authenticated-orcid":false,"given":"Marconi Rodrigues","family":"de Farias","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, School of Medicine and Life Sciences Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1  Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2006.08.013"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci4030037"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.03.010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.254.11.1291"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31286-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12740"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2010.00889.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-015-0514-6"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12696"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2010.00899.x"},{"key":"e_1_2_10_12_1","first-page":"108","volume-title":"Muller and Kirk's small animal dermatology","author":"Miller WH","year":"2013"},{"key":"e_1_2_10_13_1","unstructured":"GonzalesAJ.In vitro effects of PF\u201003394197 on kinase activity and cytokine function. zoetis study 7960Z\u201060\u201011\u2010B95 24 January 2012."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.22.12.0570"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12194"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.32932\/rpia.2022.03.076"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2003.00335.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2018.08.008"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00758.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2008.00728.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12107"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12166"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci9040149"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12047"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12088"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12087"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13134"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083197"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsec\/fiv139"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.07.041"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.11.047"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12197"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.239"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12450"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42190-1"},{"key":"e_1_2_10_36_1","unstructured":"MartinsAS.Utiliza\u00e7\u00e3o cl\u00ednica de oclacitinib no maneio da dermatite at\u00f3pica canina: Avalia\u00e7\u00e3o da resposta ao tratamento na perspetiva dos tutores (Disserta\u00e7\u00e3o de mestrado).2017. Lisboa: Faculdade de Medicina Veterin\u00e1ria \u2013 Universidade de Lisboa."}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.13327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T05:02:48Z","timestamp":1751346168000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.13327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,3]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/vde.13327"],"URL":"https:\/\/doi.org\/10.1111\/vde.13327","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,3]]},"assertion":[{"value":"2024-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}