{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T10:18:26Z","timestamp":1782296306274,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Canine interdigital furunculosis (CIF) is a complex, relapsing inflammatory condition, typically complicated by deep bacterial infections requiring prolonged systemic antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis\/Objectives<\/jats:title><jats:p>This split\u2010body study, where dogs acted as their own control, evaluated whether the adjunctive use of fluorescent light energy (FLE) could shorten the time to clinical resolution of CIF and minimise systemic antimicrobial use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Thirty\u2010five client\u2010owned dogs with signs of interdigital furunculosis in at least two paws.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This prospective, single\u2010blinded, randomised, split\u2010body multicentre clinical trial treated dogs with systemic antibiotics based on bacterial culture and sensitivity. One paw per dog was randomly selected using a coin\u2010toss method for weekly FLE application, while the other paw served as a control. Dogs were scored every 2\u2009weeks over 56\u2009days on two parameters: a global lesion score (including haemorrhagic vesicles, fistulae with draining tracts, crusts and ulcers) and neutrophils engulfing bacteria score (NES, 0\u20134). Time to clinical resolution and lesion scores were assessed and compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At Day (D)28 and D56, the FLE group showed significantly more healed paws (50% and 88%, <jats:italic>p<\/jats:italic>\u2009=\u20090.021) compared to the control (17% and 54%, <jats:italic>p<\/jats:italic>\u2009=\u20090.008). The median time to clinical resolution was shorter for the FLE group (35\u2009days) compared to the control group (56\u2009days, <jats:italic>p<\/jats:italic>\u2009=\u20090.017). No difference in NES score was observed between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>This blinded, randomised, split\u2010body clinical trial demonstrated that FLE is an effective adjunctive therapy for CIF. It reduces the time to clinical resolution and increases the resolution rate while minimising the need for antibiotics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13340","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T11:13:33Z","timestamp":1742728413000},"page":"291-301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A blinded randomised split\u2010body clinical trial evaluating the effect of fluorescent light energy on antimicrobial management of canine interdigital furunculosis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7785-9372","authenticated-orcid":false,"given":"A.","family":"Lange","sequence":"first","affiliation":[{"name":"Department of Dermatology AniCura Kleintierspezialisten Augsburg GmbH  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Dermatology AniCura Kleintierspezialisten Augsburg GmbH  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0404-3185","authenticated-orcid":false,"given":"E.","family":"Bensignor","sequence":"additional","affiliation":[{"name":"Dermatology Referral Service Clinique V\u00e9t\u00e9rinaire  Rennes\u2010Cesson France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5291-4080","authenticated-orcid":false,"given":"L.","family":"Cornegliani","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria S. Siro \u2013 Anicura  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2500-8298","authenticated-orcid":false,"given":"D.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Dermatologia Veterinaria  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Matricoti","sequence":"additional","affiliation":[{"name":"Servizi Dermatologici Veterinari  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7682-2452","authenticated-orcid":false,"given":"M.","family":"Mosca","sequence":"additional","affiliation":[{"name":"VetAgro Sup, Interactions Cells Environment Universit\u00e9 de Lyon  Marcy l'Etoile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ordeix","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Hospital Cl\u00ednic Veterinari and Departament de Medicina i Cirurgia Animals Facultat de Veterin\u00e0ria, Universitat Aut\u00f2noma de Barcelona  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Pin","sequence":"additional","affiliation":[{"name":"VetAgro Sup, Interactions Cells Environment Universit\u00e9 de Lyon  Marcy l'Etoile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4581-7263","authenticated-orcid":false,"given":"F.","family":"Scarampella","sequence":"additional","affiliation":[{"name":"Studio Dermatologico Veterinario  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Videmont","sequence":"additional","affiliation":[{"name":"Centre Hospitalier V\u00e9t\u00e9rinaire  Saint\u2010Martin Filli\u00e8re France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Yu","sequence":"additional","affiliation":[{"name":"Guelph Veterinary Specialty Hospital  Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Fantini","sequence":"additional","affiliation":[{"name":"Vetoquinol SA  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.06.028"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.05.027"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2012.09.012"},{"issue":"9","key":"e_1_2_11_5_1","first-page":"991","article-title":"Canine pododermatitis","volume":"57","author":"Bajwa J","year":"2016","journal-title":"Can Vet J"},{"key":"e_1_2_11_6_1","first-page":"201","volume-title":"Muller and Kirk's small animal dermatology. St. Louis, MO: Elsevier Mosby","author":"Miller WH","year":"2013"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2008.00662.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12735"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13156"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2021.2251-2259"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci9090505"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","unstructured":"MarchegianiA.Klox fluorescence biomodulation system proceedings 61st BSAVA congress.2018. p. 442.","DOI":"10.22233\/9781910443590.67.1"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12468"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12785"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.880349"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2020.1797778"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6643416"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11101197"},{"key":"e_1_2_11_19_1","doi-asserted-by":"crossref","unstructured":"ScapagniniG MarchegianiA RossiG ZagoM JowarskaJ WaelM.Management of all three phases of wound healing through the induction of fluorescence biomodulation using fluorescence light energy. In: Proc. SPIE 10863 photonic diagnosis and treatment of infections and inflammatory diseases II 108630W.2019.https:\/\/doi.org\/10.1117\/12.2508066","DOI":"10.1117\/12.2508066"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.03.945"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.13340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T03:00:59Z","timestamp":1746673259000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.13340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/vde.13340"],"URL":"https:\/\/doi.org\/10.1111\/vde.13340","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,21]]},"assertion":[{"value":"2024-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}