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Guidance on diagnosing surface, superficial and deep pyoderma and their underlying primary causes, is included. Recommendations aim to optimise treatment outcomes while promoting responsible antimicrobial use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Evidence was gathered from a systematic literature review of English\u2010language treatment studies for canine pyoderma up to 23 December 2023. Quality was assessed using SORT criteria and combined with authors' consensus evaluation. Recommendations were voted on in an iterative process, followed by a Delphi\u2010style feedback process before final agreement by the authors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cytology should be performed in all cases before antimicrobials are used. Topical antimicrobial therapy alone is the treatment\u2010of\u2010choice for surface and superficial pyodermas. Systemic antimicrobials should be reserved for deep pyoderma and for superficial pyoderma when topical therapy is not effective. Systemic therapy, with adjunctive topical treatment, is initially provided for 2\u2009weeks in superficial and 3\u2009weeks in deep pyoderma, followed by re\u2010examination to assess progress and manage primary causes. First\u2010choice drugs have expected efficacy against the majority of meticillin\u2010susceptible <jats:italic>Staphylococcus pseudintermedius;<\/jats:italic> for all other drugs, laboratory testing should confirm susceptibility and exclude suitability of safer alternatives. As culture and susceptibility testing are essential for rationalising systemic therapy, laboratories and practices should price them reasonably to encourage use. Proactive topical therapy using antiseptics may help prevent recurrences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>The accessibility of the skin offers excellent, achievable opportunities for antimicrobial stewardship.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vde.13342","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T03:00:56Z","timestamp":1746673256000},"page":"234-282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Antimicrobial use guidelines for canine pyoderma by the International Society for Companion Animal Infectious Diseases (ISCAID)"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0446-3729","authenticated-orcid":false,"given":"Anette","family":"Loeffler","sequence":"first","affiliation":[{"name":"Department of Clinical Science and Services Royal Veterinary College  Hatfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6290-3702","authenticated-orcid":false,"given":"Christine L.","family":"Cain","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine University of Pennsylvania, School of Veterinary Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1537-0074","authenticated-orcid":false,"given":"Llu\u00eds","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Nishifuji","sequence":"additional","affiliation":[{"name":"Division of Animal Life Science Graduate School of Agriculture, Tokyo University of Agriculture and Technology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Varjonen","sequence":"additional","affiliation":[{"name":"Anicura Albano Animal Hospital  Danderyd Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G.","family":"Papich","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Guardabassi","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Sciences University of Copenhagen  Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4601-4566","authenticated-orcid":false,"given":"Si\u00e2n M.","family":"Frosini","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Services Royal Veterinary College  Hatfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi N.","family":"Barker","sequence":"additional","affiliation":[{"name":"Langford Vets and Bristol Veterinary School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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