{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T08:19:57Z","timestamp":1762417197262,"version":"build-2065373602"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012895","name":"Zoetis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["05512\u20102020","441651\u20102013","491953\u20102016"],"award-info":[{"award-number":["05512\u20102020","441651\u20102013","491953\u20102016"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["9483","24601"],"award-info":[{"award-number":["9483","24601"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004489","name":"Mitacs","doi-asserted-by":"publisher","award":["11643"],"award-info":[{"award-number":["11643"]}],"id":[{"id":"10.13039\/501100004489","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gabapentin reportedly decreases central sensitisation, a disorder associated with chronic pruritus in humans, although this is not well documented in cats. Its combined use with the standard antipruritic therapy for feline atopic skin syndrome (FASS) is not yet described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the impact of prednisolone, ciclosporin or placebo, with or without gabapentin, on lesional scores and actimetry in FASS cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty\u2010six cats from a laboratory colony with naturally acquired FASS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Materials<\/jats:title>\n                    <jats:p>\n                      Following a 12\u2010week washout period, cats were allocated to one of three groups: prednisolone (1\u2009mg\/kg,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099), ciclosporin (7\u2009mg\/kg,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098) and placebo (Avicel,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099). Treatments were administered orally, once daily for 5\u2009weeks (Week [W]0 to W4), then combined with gabapentin (10\u201315\u2009mg\/kg) for another 3\u2009weeks. The Feline Dermatitis Extent and Severity Index (FeDESI) was assessed at baseline and W2, W4 and W7. Actimetry was recorded and analysed over weekend (WE) time points. A repeated\u2010measures generalised mixed model was applied using the zero\u2010inflated negative binomial (FeDESI) or log\u2010normal (actimetry) distribution (\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009=\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Prednisolone alone significantly improved FeDESI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), while ciclosporin required the addition of gabapentin to achieve a significant effect (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.034). Gabapentin decreased FeDESI scores in all groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and demonstrated the highest incidence rate ratio (2.59) compared to placebo. Improvements in FeDESI were associated with significant (corresponding in intensity) decreases in motor activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>Gabapentin, particularly when combined with prednisolone or ciclosporin, may reduce lesional score and actimetry\u2010assessed itch in FASS cats, suggesting a potential central sensitisation in some cats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.70000","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T04:15:00Z","timestamp":1752812100000},"page":"814-824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Gabapentin Administered With Prednisolone, Ciclosporin or a Placebo on Clinical Outcomes and Motor Activity in Cats With Atopic Skin Syndrome: A Prospective, Blinded, Placebo\u2010Controlled Study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8247-4210","authenticated-orcid":false,"given":"Jeanne","family":"Morency","sequence":"first","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire Universit\u00e9 de Montr\u00e9al  St\u2010Hyacinthe Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0209-5261","authenticated-orcid":false,"given":"\u00c9ric","family":"Troncy","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire Universit\u00e9 de Montr\u00e9al  St\u2010Hyacinthe Canada"},{"name":"Groupe de Recherche en Pharmacologie Animale du Qu\u00e9bec (GREPAQ)  St\u2010Hyacinthe Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6798-8899","authenticated-orcid":false,"given":"Ali\u00e9nor","family":"Delsart","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire Universit\u00e9 de Montr\u00e9al  St\u2010Hyacinthe Canada"},{"name":"Groupe de Recherche en Pharmacologie Animale du Qu\u00e9bec (GREPAQ)  St\u2010Hyacinthe Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4286-6534","authenticated-orcid":false,"given":"Colombe","family":"Otis","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire Universit\u00e9 de Montr\u00e9al  St\u2010Hyacinthe Canada"},{"name":"Groupe de Recherche en Pharmacologie Animale du Qu\u00e9bec (GREPAQ)  St\u2010Hyacinthe Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5046-7926","authenticated-orcid":false,"given":"J\u00e9r\u00f4me R. 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