{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:06:41Z","timestamp":1792624001782,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Effective management of otitis externa (OE) requires addressing all contributing factors to prevent chronicity and recurrence. Evidence on the long\u2010term efficacy of topical corticosteroids in preventing recurrence and secondary infections remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This retrospective noncontrolled study evaluated the efficacy of hydrocortisone aceponate (HCA) in resolving non\u2010infectious chronic or recurrent (CR)\u2010OE with or without proliferative changes, and preventing recurrence of acute episodes and secondary infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>A total of 63 owned dogs (115 ears) with unilateral or bilateral non\u2010infectious CR\u2010OE were included. Most ears were enrolled after resolving infectious otitis, as persistent inflammation or recurrence required further management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Clinical records from two dermatology referral centres (February 2022\u2013July 2023) were reviewed. Dogs were included if they had recurrent otitis for over a year (\u2265\u20091\u2009year) or chronic otitis (\u2265\u20091\u2009month). Otitis severity was assessed using the Otitis Index Score (OTIS3) scale, and by grading stenosis and hyperplasia severity. Enrolled patients received HCA 0.584\u2009mg\/mL at weight\u2010adjusted doses. A reactive phase continued until OTIS3\u2009&lt;\u20092, followed by a proactive phase with regimens adapted to otitis severity. Concurrent treatments were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Recurrence was not observed in 79.1% of ears (mean follow\u2010up 202.6\u2009days). Among 24 relapsed ears, 29.17% recurred after treatment discontinuation. Higher recurrence was associated with stopping therapy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and recent bacterial otitis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). No adverse effects were noted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>The use of HCA appears to be an effective and safe option for reactive and proactive management of non\u2010infectious CRC\u2010OE, reducing recurrences and improving patient and owner quality\u2010of\u2010life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.70008","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T10:39:37Z","timestamp":1754303977000},"page":"870-878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hydrocortisone Aceponate for Chronic Otitis: Long\u2010Term Efficacy"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1285-2158","authenticated-orcid":false,"given":"C.","family":"Lorente\u2010M\u00e9ndez","sequence":"first","affiliation":[{"name":"Department of Animal Medicine and Surgery, Veterinary Medicine School Complutense University of Madrid  Madrid Spain"},{"name":"LABOKLIN GmbH &amp; Co. KG  Bad Kissingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4106-2278","authenticated-orcid":false,"given":"D.","family":"Alonso\u2010Miguel","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine and Surgery, Veterinary Medicine School Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40575-021-00106-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.23.01.0002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2007.00619.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2003.10.006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.14868"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2003.10.009"},{"key":"e_1_2_10_8_1","first-page":"97","article-title":"Canine Otitis Externa\u2014Treatment and Complications","volume":"60","author":"Bajwa J.","year":"2019","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12194"},{"key":"e_1_2_10_10_1","article-title":"A Blinded, Randomized, Placebo\u2010Controlled, Dose Determination Trial of Lokivetmab (ZTS\u201000103289), a Caninized, Anti\u2010Canine IL\u201031 Monoclonal Antibody in Client Owned Dogs With Atopic Dermatitis","volume":"27","author":"Michels G. M.","year":"2016","journal-title":"Veterinary Dermatology"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12166"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2003.00318.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12977"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13224"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00756.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12285"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12909"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12163"},{"key":"e_1_2_10_19_1","volume-title":"Inability to Assess Tympanic Membrane Integrity in Infectious Otitis Externa Before Treatment","author":"Alonso\u2010Miguel D.","year":"2024"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2002.00288.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1985.46.06.1351"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/inp.i470"},{"key":"e_1_2_10_23_1","unstructured":"C.Griffin \u201cClassifying Cases of Otitis Externa the PPSP System.\u201d In: Proceedings of ESVD Workshop on Otitis. St Helens UK: 2010."},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2010.00925.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.98"},{"key":"e_1_2_10_26_1","volume-title":"Safety of a Proactive Therapy With Hydrocortisone Aceponate (Cortavance) in Ears to Reduce the Risk of Recurrence of Otitis Externa in Atopic Dogs: A Retrospective Study","author":"Bensignor E.","year":"2017"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.70008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T08:15:17Z","timestamp":1762416917000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.70008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,4]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/vde.70008"],"URL":"https:\/\/doi.org\/10.1111\/vde.70008","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,4]]},"assertion":[{"value":"2024-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}