{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T08:21:05Z","timestamp":1762417265094,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Administration of interleukin (IL)\u201031 to healthy dogs has been used in preclinical drug testing to evaluate the antipruritic effect of novel medications through a \u201cpreventative\u201d design approach (i.e., drugs are given before IL\u201031 administration).<\/jats:p>\n <\/jats:sec>\n \n Hypothesis\/Objectives<\/jats:title>\n Develop and validate a \u201creactive\u201d intradermal IL\u201031\u2010induced pruritus model in healthy dogs by administering oral oclacitinib.<\/jats:p>\n <\/jats:sec>\n \n Animals<\/jats:title>\n Eight adult, healthy research\u2010bred beagles.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n A blinded, randomised, cross\u2010over study. All dogs received either intradermal recombinant canine IL\u201031 with or without a single dose of oral oclacitinib given afterward; cross\u2010over treatment was administered following a 4\u2010week washout period.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Oclacitinib reduced the total (\n p<\/jats:italic>\n \u2009=\u20090.0252) and local (\n p<\/jats:italic>\n \u2009=\u20090.0078) pruritic behaviour seconds after intradermal IL\u201031 injections. It also reduced the total seconds of scratching (\n p<\/jats:italic>\n \u2009=\u20090.0078), chewing\/biting (\n p<\/jats:italic>\n \u2009=\u20090.0078) and head\u2010shaking (\n p<\/jats:italic>\n \u2009=\u20090.0255) behaviours. No significant reduction in licking was observed. Decreases in total pruritic seconds in this \u201creactive\u201d model following oclacitinib administration were observed at 120\u2013180\u2009min (\n p<\/jats:italic>\n \u2009=\u20090.0058), 180\u2013240\u2009min (\n p<\/jats:italic>\n \u2009=\u20090.0075) and 240\u2013300\u2009min (\n p<\/jats:italic>\n \u2009=\u20090.0241). Likewise, decreases in local pruritic behaviour seconds were observed at 60\u2013120\u2009min (\n p<\/jats:italic>\n \u2009=\u20090.0498) and 240\u2013300\u2009min (\n p<\/jats:italic>\n \u2009=\u20090.0343).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Clinical Relevance<\/jats:title>\n The study established the first \u201creactive\u201d canine intradermal IL\u201031 itch model in healthy dogs. One\u2010time oral administration of oclacitinib significantly reduced the incidence of pruritic behaviours. Novel antipruritic medications can be assessed and compared using this \u201creactive\u201d model in future preclinical trials.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vde.70010","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T09:26:37Z","timestamp":1753781197000},"page":"838-846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of One\u2010Time Oral Oclacitinib Administration on Pruritic Behaviours After Intradermal Interleukin\u201031\u2010Induced Pruritus Injections (\u201cReactive\u201d Model) in Healthy Dogs: A Blinded, Randomised, Cross\u2010Over Study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4519-5100","authenticated-orcid":false,"given":"Renato","family":"Leon","sequence":"first","affiliation":[{"name":"Department of Small Animal Medicine and Surgery College of Veterinary Medicine, University of Georgia Athens Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haley","family":"Starr","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery College of Veterinary Medicine, University of Georgia Athens Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4785-4121","authenticated-orcid":false,"given":"Frane","family":"Banovic","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery College of Veterinary Medicine, University of Georgia Athens Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00758.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.05.007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2010.00954.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.0902a03"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01098.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14791"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2013.10.017"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.048"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12316"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2697"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13794"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12101"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12376"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20873"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12280"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci10050329"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.13065"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13231"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12754"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12818"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.70010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T08:15:18Z","timestamp":1762416918000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.70010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,29]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/vde.70010"],"URL":"https:\/\/doi.org\/10.1111\/vde.70010","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"type":"print","value":"0959-4493"},{"type":"electronic","value":"1365-3164"}],"subject":[],"published":{"date-parts":[[2025,7,29]]},"assertion":[{"value":"2025-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}