{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:13:37Z","timestamp":1793279617011,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009231","name":"European Society of Veterinary Dermatology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009231","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Dogs with moderate\u2010to\u2010severe leishmaniosis develop a strong nonprotective humoral response which is mainly associated with anti\u2010\n                      <jats:italic>Leishmania infantum<\/jats:italic>\n                      antibodies. Humoral immune response also plays an important role in canine atopic dermatitis (cAD) and is associated with allergen\u2010specific immunoglobulin (Ig)E.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To compare the serum allergen\u2010specific IgE concentration in dogs with leishmaniosis and high levels of anti\u2010L. infantum\u2010specific antibodies with Leishmania seronegative clinically healthy and atopic dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Serum samples from 47 dogs with leishmaniosis without cAD and high anti\u2010\n                      <jats:italic>L. infantum<\/jats:italic>\n                      antibodies were included and compared with serum from 30 atopic and 33 clinically healthy dogs. Serum samples were analysed using a commercial kit for the quantitative measurement of allergen\u2010specific IgE. Dogs with anti\u2010cross\u2010reactive carbohydrate determinants (CCD)\u2010IgE were excluded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The proportion of dogs positive for at least one allergen was significantly higher in dogs with leishmaniosis (40 of 40) than in healthy (18 of 28) and atopic dogs (10 of 30) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, Fisher's exact test). The median allergen\u2010specific IgE concentration was 7.1\u2009U\/mL in leishmaniotic dogs, 4.7\u2009U\/mL in atopic dogs and 1.4\u2009U\/mL in healthy dogs. A significant difference was observed between dogs with leishmaniosis and healthy dogs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, Wilcoxon\u2013Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      \u2010test), while no differences were found between leishmaniotic and atopic dogs, and atopic and healthy dogs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>\n                      Dogs with moderate\u2010to\u2010severe leishmaniosis and high levels of anti\u2010\n                      <jats:italic>L. infantum<\/jats:italic>\n                      antibodies produce high levels of serum allergen\u2010specific IgE that do not appear to be of clinical relevance. Clinicians should cautiously interpret serological allergen tests in dogs with leishmaniosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.70020","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T05:00:42Z","timestamp":1755579642000},"page":"122-131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum Allergen\u2010Specific Immunoglobulin E Response in Dogs With Moderate\u2010To\u2010Severe Leishmaniosis"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2548-4286","authenticated-orcid":false,"given":"Maria","family":"Cabr\u00e9","sequence":"first","affiliation":[{"name":"Departament de Medicina i Cirurgia Animals Universitat Aut\u00f2noma de Barcelona  Bellaterra Spain"},{"name":"Fundaci\u00f3 Hospital Cl\u00ednic Veterinari, Universitat Aut\u00f2noma de Barcelona  Bellaterra Spain"},{"name":"Canis Hospital Veterinari  Girona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8479-4896","authenticated-orcid":false,"given":"Laia","family":"Solano\u2010Gallego","sequence":"additional","affiliation":[{"name":"Departament de Medicina i Cirurgia Animals Universitat Aut\u00f2noma de Barcelona  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"DeBoer","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3631-8358","authenticated-orcid":false,"given":"Laura","family":"Ordeix","sequence":"additional","affiliation":[{"name":"Departament de Medicina i Cirurgia Animals Universitat Aut\u00f2noma de Barcelona  Bellaterra Spain"},{"name":"Fundaci\u00f3 Hospital Cl\u00ednic Veterinari, Universitat Aut\u00f2noma de Barcelona  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