{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:05:54Z","timestamp":1769634354154,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Dermal arteritis of the nasal philtrum (DANP) is an uncommon and poorly understood condition affecting large vessels of the nasal philtrum in dogs. Medical and\/or surgical management has been proposed with inconsistent results and incomplete resolution. Carbon dioxide (CO\n 2<\/jats:sub>\n ) lasers are used for a variety of soft tissue procedures and could be beneficial in DANP owing to their intrinsic haemostatic capabilities.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n The aim of this retrospective study was to evaluate the use of CO\n 2<\/jats:sub>\n laser ablation for the treatment of unresponsive DANP in dogs.\n <\/jats:p>\n <\/jats:sec>\n \n Animals<\/jats:title>\n Five client\u2010owned dogs with a presumptive or definitive diagnosis of DANP and unresponsive to standard treatments were included.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n CO\n 2<\/jats:sub>\n laser ablation of the ulcer and the adjacent tissue was performed until complete resolution of the nasal bleeding was achieved.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n This cohort included two Saint Bernards, one great Dane, one American bulldog and one mixed\u2010breed dog. There were four neutered males and one spayed female with a median age of 7 (range 6\u201310) years. The procedure led to complete resolution of the bleeding within a few days post\u2010laser procedure. A follow\u2010up ranging from 1 to 12\u2009months reported a lack of relapses of bleeding and ulceration in all dogs.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Clinical Relevance<\/jats:title>\n \n In this study of five dogs, a single CO\n 2<\/jats:sub>\n laser ablation was practical, cost\u2010effective, and provided full remission of the clinical signs of DANP that had been unresponsive to standard treatment. This is the first report describing CO\n 2<\/jats:sub>\n laser as a potential alternative treatment for difficult cases of canine DANP.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vde.70022","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T10:31:34Z","timestamp":1756204294000},"page":"132-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Use of a Single Carbon Dioxide (\n \n CO\n 2<\/sub>\n <\/scp>\n ) Laser Procedure as Medium\u2010To\u2010Long\u2010Term Treatment for Unresponsive Dermal Arteritis of the Nasal Philtrum in Dogs: A Retrospective Study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4893-4289","authenticated-orcid":false,"given":"Domenico","family":"Santoro","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences College of Veterinary Medicine, University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2002.00309.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12790"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2008.00691.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12502"},{"key":"e_1_2_10_6_1","first-page":"115","article-title":"Successful Medical and Surgical Treatment of Dermal Arteritis of the Nasal Philtrum in a Saint Bernard Dog","volume":"5","author":"Vuolo S.","year":"2014","journal-title":"Veterinary Medicine"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470344491.ch10"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(94)90227-5"},{"key":"e_1_2_10_9_1","first-page":"1","article-title":"Comparison of the Influence of CO2\u2010Laser and Scalpel Skin Incisions on the Surgical Wound Healing Process","volume":"1","author":"Carreira L. M.","year":"2016","journal-title":"ARC Journal of Anesthesiology"},{"key":"e_1_2_10_10_1","first-page":"3","article-title":"Study on the Plasmatic CRP Level Variation in Dogs Undergoing Surgery With CO2 Laser and Scalpel Blade Incisions in a Pre\u2010 and Post\u2010Surgical Time\u2010Point","volume":"3","author":"Carreira L. M.","year":"2018","journal-title":"ARC Journal of Anesthesiology"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1408409"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12992"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2009.01265.x"},{"key":"e_1_2_10_14_1","first-page":"1326","article-title":"Connective Tissue Remodeling Induced by Carbon Dioxide Laser Resurfacing of Photodamaged Human Skin","volume":"140","author":"Orringer J. S.","year":"2004","journal-title":"Archives of Dermatology"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107559"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.70022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vde.70022","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.70022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T09:07:21Z","timestamp":1769591241000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.70022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/vde.70022"],"URL":"https:\/\/doi.org\/10.1111\/vde.70022","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]},"assertion":[{"value":"2025-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}