{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:14:36Z","timestamp":1769634876550,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Normal hydration of the canine epidermis is imperative for cutaneous homeostasis. Xerosis may be encountered in canine atopic dermatitis and is aggravated by topical antiseptics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis and Objectives<\/jats:title>\n                    <jats:p>To evaluate the hydrating properties and the safety of a spray (Sensiderm spray; MP Labo) when applied after shampooing healthy dogs with a chlorhexidine 2%\/miconazole 2% product.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twelve clinically healthy, privately owned dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Dogs were clipped on the top of the head (control site), right and left lateral thorax. They were bathed on the body trunk with the chlorhexidine 2%\/miconazole 2% shampoo and subsequently sprayed with Sensiderm on their randomly selected right or left side of the thorax. Skin hydration was measured by electrical capacitance using a corneometer on the three sites before (time point [T]0), and 1\u20132\u2009h (T1), 6\u2009h (T2), 24\u2009h (T3), 48\u2009h (T4) and 72\u2009h (T5) after interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two\u2010way repeated\u2010measures ANOVA showed a significant effect of time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015) and a significant time\u2013treatment interaction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023) on skin hydration. One\u2010way repeated\u2010measures ANOVA showed that the effect of time was significant only on the Sensiderm spray\u2010treated site, where skin hydration increased over baseline at T1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009; 95% confidence interval [CI]\u2009=\u20093.158\u201317.231), peaked at T2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.014 and 95% CI \u2265\u20091.680 compared with T0, T3, T4 and T5) and remained increased at T3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.037 and 95% CI \u2265\u20090.482 compared with T0 and T5). No treatment\u2010related adverse effects were seen.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>Sensiderm spray was safe, and it increased hydration of healthy canine skin for \u2265\u200924\u2009h.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.70025","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T08:25:12Z","timestamp":1756715112000},"page":"140-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of a Spray Containing Occlusive Agents, Humectants and Physiological Lipids on Skin Hydration of Healthy Dogs When Applied After Bathing With a Chlorhexidine 2%\/Miconazole 2% Shampoo"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1871-0594","authenticated-orcid":false,"given":"Adamantia","family":"Pseftogka","sequence":"first","affiliation":[{"name":"Clinic of Medicine Faculty of Veterinary Science, University of Thessaly  Karditsa Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4478-3591","authenticated-orcid":false,"given":"Elisabeta","family":"Samuel (Badulescu)","sequence":"additional","affiliation":[{"name":"Clinic of Medicine Faculty of Veterinary Science, University of Thessaly  Karditsa Greece"},{"name":"ArtVetDerm  Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8451-3708","authenticated-orcid":false,"given":"Manolis K.","family":"Chatzis","sequence":"additional","affiliation":[{"name":"Clinic of Medicine Faculty of Veterinary Science, University of Thessaly  Karditsa Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-3371","authenticated-orcid":false,"given":"Manolis N.","family":"Saridomichelakis","sequence":"additional","affiliation":[{"name":"Clinic of Medicine Faculty of Veterinary Science, University of Thessaly  Karditsa 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