{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:25:05Z","timestamp":1785774305647,"version":"3.56.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Otitis externa (OE) with secondary bacterial or yeast infection is a common problem in small animal practice. Cold physical plasma (CPP) has been reported to have antimicrobial activity in\u00a0vitro.<\/jats:p>\n <\/jats:sec>\n \n Hypothesis\/Objectives<\/jats:title>\n This randomised, blinded, prospective study assessed the influence of additional CPP treatment on the recovery of canine OE with secondary infection.<\/jats:p>\n <\/jats:sec>\n \n Animals<\/jats:title>\n Twenty\u2010one dogs with bilateral clinical OE and cytological evidence of infection were included.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n An ear flush was performed with saline solution in all dogs. Additionally, one ear of each dog, chosen in a prospective randomised fashion, was treated with CPP for 30\u2009s. Afterwards, both ears were treated with a depot ear medication containing betamethasone, terbinafine and florfenicol. Seven days later, the depot medication was administered again as recommended by the manufacturer. On Day (D) 0, D7 and D21, a clinical otic score and a validated semiquantitative cytological score were compared with a Friedman test and Dunn's multiple comparison test.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Ears treated additionally with CPP showed lower otic scores after 21\u2009days compared to nontreated ears, although this difference was not significant (\n p<\/jats:italic>\n \u2009=\u20090.08). Cytological scores improved over 21\u2009days with cocci in CPP\u2010treated (\n p<\/jats:italic>\n \u2009=\u20090.003) and nontreated ears (\n p<\/jats:italic>\n \u2009=\u20090.02). With yeast, there was significant improvement in CPP\u2010treated (\n p<\/jats:italic>\n \u2009=\u20090.0002) ears in contrast to nontreated ears. With rods, the improvement was not statistically significant in either group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Clinical Relevance<\/jats:title>\n CPP treatment seems to be a promising option as an additional treatment after ear flushing.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vde.70027","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T08:21:12Z","timestamp":1757492472000},"page":"103-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Single Cold Atmospheric Plasma Therapy May Improve the Treatment Outcome of Canine Otitis Externa With Secondary Infection"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5835-5910","authenticated-orcid":false,"given":"Ralf S.","family":"Mueller","sequence":"first","affiliation":[{"name":"LMU Small Animal Clinic University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosima","family":"Bouassiba","sequence":"additional","affiliation":[{"name":"Small Animal Practice, Alte Manufaktur Viersen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40575-021-00106-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00758.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2007.00619.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2002.00285.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2016.09.010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.10-0488"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268818003278"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12811"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.24425\/pjvs.2023.145052"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.719"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2013.0591"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01075.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160667"},{"key":"e_1_2_9_15_1","first-page":"161","article-title":"In\u2010Vivo Efficacy of a Commercial Ear Antiseptic Containing Chlorhexidine and Tris\u2010EDTA. A Randomised, Placebo\u2010Controlled, Double\u2010Blinded Comparative Trial","volume":"40","author":"Bouassiba C.","year":"2012","journal-title":"Tierarztliche Praxis Ausgabe K Kleintiere Heimtiere"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12163"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12433"},{"key":"e_1_2_9_18_1","first-page":"13","article-title":"In Vitro Antibacterial Effects of Non\u2010Thermal Atmospheric Plasma Irradiation on Staphylococcus pseudintermedius and Pseudomonas Aeruginosa","volume":"23","author":"Bae S.","year":"2020","journal-title":"Polish Journal of Veterinary Sciences"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13012"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13030"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12971"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/avj.12007"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.13780"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13287"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.70027","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vde.70027","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.70027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T09:07:04Z","timestamp":1769591224000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.70027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,10]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/vde.70027"],"URL":"https:\/\/doi.org\/10.1111\/vde.70027","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,10]]},"assertion":[{"value":"2025-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}