{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:09:43Z","timestamp":1778641783077,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100032199","name":"Stallergenes Greer France","doi-asserted-by":"publisher","award":["041124"],"award-info":[{"award-number":["041124"]}],"id":[{"id":"10.13039\/100032199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Maropitant citrate (Cerenia; Zoetis) is a neurokinin\u20101 receptor antagonist that inhibits binding of substance P, and is approved to prevent acute emesis and motion sickness in dogs. Maropitant is often administered before sedation with \u03b12\u2010agonists to reduce the risk of vomiting. Many medications interfere with intradermal test (IDT) results and it is unknown if maropitant citrate alters IDT reactivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the influence of maropitant citrate on IDT reactivity in dogs with canine atopic dermatitis (cAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Twenty client\u2010owned dogs with cAD were enrolled in a randomised, controlled, blinded, comparative trial. Each IDT was read independently by a dermatology resident and a referral clinician. Subjective (0\u20134) and objective (mm diameter) wheal scores were measured 15\u2009min after intradermal injections. Four positive pollen allergens with established irritancy threshold concentrations (ITC) were selected for assessment in the next phase. Following completion of the initial IDT, maropitant citrate (1\u2009mg\/kg) was administered intravenously. A second, randomised, blinded IDT was performed using the four positive allergens injected in triplicate, with controls injected in duplicate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Histamine (objective mean difference [MD]\u2009=\u20091.1\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and positive allergen (objective MD\u2009=\u20090.4\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007; subjective MD\u2009=\u20090.2\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) wheal sizes were statistically larger post\u2010maropitant citrate. The proportions of positive allergen scores were not significantly different pre\u2010 and post\u2010maropitant citrate (objective: 48 of 80 pre\u2010 vs. 56 of 80 post\u2010,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.09; subjective: 80 of 80 pre\u2010 vs. 77 of 80 post\u2010,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.25). No adverse events were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>Intravascular maropitant citrate increases wheal size, yet the effect on allergen selection for clinical treatment remains equivocal.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.70045","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T06:56:11Z","timestamp":1766732171000},"page":"405-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of Maropitant Citrate on Pollen and Control Intradermal Test Reactivity in Atopic Dogs: A Randomised, Controlled, Blinded Trial"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9937-2268","authenticated-orcid":false,"given":"Aubrey G.","family":"Gould","sequence":"first","affiliation":[{"name":"Animal Dermatology Clinic  Mount Pleasant South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa H.","family":"Akucewich","sequence":"additional","affiliation":[{"name":"Animal Dermatology Clinic  Mount Pleasant South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall C.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Animal Dermatology Clinic  Mount Pleasant South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah T.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Animal Dermatology Clinic  Summerville South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudayna","family":"Ghubash","sequence":"additional","affiliation":[{"name":"Animal Dermatology Group  Newport Beach California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci4030037"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(01)00348-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-015-0515-5"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yasa.2021.07.004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(01)00299-9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1992.200.04.507"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(01)00313-0"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1991.52.09.1484"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.2000.00205.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13175"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2001.62.1073"},{"key":"e_1_2_11_13_1","unstructured":"Zoetis \u201cDexdomitor (Dexmedetomidine Hydrochloride) Package Insert Zoetis Inc \u201d2015 www.zoetisuc.com\/products\/dogs\/dexdomitor."},{"key":"e_1_2_11_14_1","first-page":"885","article-title":"A Review of the Physiological Effects of alpha2\u2010Agonists Related to the Clinical Use of Medetomidine in Small Animal Practice","volume":"44","author":"Sinclair M. 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