{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:10:21Z","timestamp":1778641821421,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D23CA\u2010801"],"award-info":[{"award-number":["D23CA\u2010801"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Targeted antimicrobial therapy for canine otitis externa (\n OE<\/jats:styled-content>\n ) represents an opportunity for antimicrobial stewardship. Fosmidomycin selectively inhibits the non\u2010mevalonate pathway for isoprenoid biosynthesis utilised by canine\u2010adapted, and not human\u2010adapted, staphylococci.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To evaluate the safety and efficacy of fosmidomycin for treatment of bacterial\n OE<\/jats:styled-content>\n compared with enrofloxacin.\n <\/jats:p>\n <\/jats:sec>\n \n Animals<\/jats:title>\n \n Fifteen client\u2010owned dogs with bilateral bacterial\n OE<\/jats:styled-content>\n were enrolled.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n Fosmidomycin stability in solution for 28\u2009days was confirmed before trial commencement. A \u2018split body\u2019 design was used: each ear canal was randomised to receive a solution of fosmidomycin or enrofloxacin applied twice daily for 28\u2009days, combined with a tapering anti\u2010inflammatory course of oral prednisone. Owners and investigators were blinded to treatments. Dogs were evaluated at Day (D)0,\n D14<\/jats:styled-content>\n and\n D28<\/jats:styled-content>\n with clinical scores (0\u20133 otitis index score [\n OTIS3<\/jats:styled-content>\n ], ear cytological results, pain) and owner assessments (pruritus scores for each ear, quality\u2010of\u2010life scores and a hearing questionnaire). On\n D28<\/jats:styled-content>\n , owners and investigators assessed global treatment efficacy for each ear.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Treatment group did not significantly influence clinical scores; cytological scores,\n OTIS3<\/jats:styled-content>\n scores and pruritus scores significantly improved for both groups over the trial period. Treatment efficacy for both ears was assessed as good\u2010to\u2010excellent by owners and investigators for the majority of dogs. No safety concerns were identified.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Clinical Relevance<\/jats:title>\n \n Fosmidomycin and enrofloxacin performed comparably for topical treatment of bacterial otitis in this study. Fosmidomycin is a promising targeted antimicrobial for canine bacterial infections while limiting selection for antimicrobial resistance in human pathogens such as\n \n Staphylococcus aureus<\/jats:italic>\n <\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vde.70049","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T07:05:18Z","timestamp":1770102318000},"page":"427-436","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fosmidomycin for the Treatment of Canine Otitis Externa: A Randomised, Double\u2010Blinded, Controlled \u2018Split Body\u2019 Clinical Trial"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4364-2326","authenticated-orcid":false,"given":"Lindsey E.","family":"Citron","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine University of Pennsylvania, School of Veterinary Medicine Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4654-0569","authenticated-orcid":false,"given":"Darko","family":"Stefanovski","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies\u2014New Bolton Center, School of Veterinary Medicine University of Pennsylvania Kennett Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3247-1718","authenticated-orcid":false,"given":"Youwen","family":"You","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies\u2014New Bolton Center, School of Veterinary Medicine University of Pennsylvania Kennett Pennsylvania USA"},{"name":"Pennsylvania Equine Toxicology & Research Laboratory West Chester Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3013-5921","authenticated-orcid":false,"given":"Rachel","family":"Proctor","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies\u2014New Bolton Center, School of Veterinary Medicine University of Pennsylvania Kennett Pennsylvania USA"},{"name":"Pennsylvania Equine Toxicology & Research Laboratory West Chester Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Watson","sequence":"additional","affiliation":[{"name":"Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7376-3861","authenticated-orcid":false,"given":"Julie","family":"Randall","sequence":"additional","affiliation":[{"name":"Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6290-3702","authenticated-orcid":false,"given":"Christine L.","family":"Cain","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine University of Pennsylvania, School of Veterinary Medicine Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.23.10.0239"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12826"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2020.10.003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00842.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00258-16"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15121553"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.21.2.224"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.2.735-738.2003"},{"key":"e_1_2_11_10_1","unstructured":"\u201cFosmidomycin: A New Phosphonic Acid Antibiotic. 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