{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:10:06Z","timestamp":1789171806435,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002679","name":"Adnan Menderes \u00dcniversitesi","doi-asserted-by":"publisher","award":["VTF\u201023014\u2010 Scientific Research Projects Unit\u2010"],"award-info":[{"award-number":["VTF\u201023014\u2010 Scientific Research Projects Unit\u2010"]}],"id":[{"id":"10.13039\/501100002679","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cold atmospheric plasma (CAP) offers a novel, nonpharmacological approach with potent antimicrobial, anti\u2010inflammatory and wound\u2010healing properties without harming healthy tissue. In\u00a0vitro studies have demonstrated its antimicrobial efficacy against key pathogens implicated in canine otitis externa (OE), a condition prone to chronicity if poorly managed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study evaluated CAP's therapeutic efficacy and safety in treating canine acute OE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty\u2010two dogs with bilateral acute OE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Dogs were divided into two equal groups with different bilateral treatment protocols. In Group 1, one ear was treated twice daily with topical antibiotic\/antifungal\/corticosteroid for 10\u2009days (STD\n                      <jats:sub>1<\/jats:sub>\n                      ), while the opposite ear was treated with CAP on Day (D)0 and D5 (CAP\n                      <jats:sub>1<\/jats:sub>\n                      ). In Group 2, one ear received the same topical drug protocol (STD\n                      <jats:sub>2<\/jats:sub>\n                      ), while CAP was applied to the opposite ear on D0, D3, D6 and D9. 0\u20133 otitis index score (OTIS\u20103) and cytological score were assessed on D0, D5, D10 and D15. Treatment response was assessed by the investigator and owners on D5, D10 and D15.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant reductions in OTIS\u20103 and cytological score were observed over time in both CAP groups, similar to STD groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Treatment response in CAP groups was rated good\u2010to\u2010excellent by nearly all investigators and owners. CAP demonstrated high tolerability, with no adverse effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>CAP may represent a promising adjunctive therapy in the management of acute OE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.70063","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:25:20Z","timestamp":1773390320000},"page":"797-805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Open\u2010Label Split\u2010Body Clinical Trial Evaluating Therapeutic Efficacy and Safety of Cold Atmospheric Plasma in Canine Acute Otitis Externa"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7096-7100","authenticated-orcid":false,"given":"Alanur","family":"Bak\u0131r","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Veterinary Medicine Ayd\u0131n Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7739-3477","authenticated-orcid":false,"given":"Claudia Susanne","family":"Nett\u2010Mettler","sequence":"additional","affiliation":[{"name":"vetderm.ch \u2013 Dermatologie und Allergologie f\u00fcr Tiere  Cham and Zumikon Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8399-7082","authenticated-orcid":false,"given":"Bulent","family":"Ulutas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Veterinary Medicine Ayd\u0131n Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(88)50076-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2003.10.005"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2011.01058.x"},{"key":"e_1_2_11_5_1","first-page":"45","article-title":"Prospective Study of the Effect of Otitis Externa Before and After Treatment on 20 Owners' Assessment of Their and Their Dog's Quality of Life","volume":"27","author":"Jamet J. 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