{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:58:15Z","timestamp":1787497095549,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Off\u2010label oclacitinib use for feline dermatoses management is increasing despite the paucity of data regarding optimal dose and adverse events (AEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Review AEs, clinical efficacy, and dose regimens in cats prescribed oclacitinib.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Retrospective case series of 238 privately owned cats prescribed oclacitinib for dermatological disease. Signalment, history, laboratory abnormalities, oclacitinib dosage (mg\/kg\/day), treatment duration and AEs using a modified Naranjo Adverse Drug Reaction Probability Scale were retrieved from medical records spanning August 2014 to May 2024. Clinical efficacy was estimated using a pruritus Visual Analogue Scale and medical record lesional descriptions; categorised as complete, partial or no response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean (\n                      <jats:italic>x\u0304<\/jats:italic>\n                      ) initial dosage prescribed was 1.89\u2009mg\/kg\/day. Monotherapy controlled clinical signs in 140 of 238 cats (59%), including 83 of 140 cats (59%) on twice daily (\n                      <jats:italic>x\u0304<\/jats:italic>\n                      \u2009=\u20091.85\u2009mg\/kg\/day) and 57 of 140 cats (41%) on once daily administration (\n                      <jats:italic>x\u0304<\/jats:italic>\n                      \u2009=\u20091.05\u2009mg\/kg\/day). The median treatment duration was 271.5\u2009days (range 1\u2009day\u20137.5\u2009years). Main diagnoses successfully managed included feline atopic skin syndrome (61%) and pemphigus foliaceus (29%). Thirty\u2010three \u2018definite\u2019 or \u2018probable\u2019 AEs were observed in 32 of 238 cats including: neutropaenia 6.3% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915), gastrointestinal 4% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099), lethargy 1.7% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094), infection 0.8% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092), hyperactivity 0.4% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091), elevated alanine transaminase 0.4% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091) and elevated creatinine 0.4% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>Off\u2010label oclacitinib administration in cats appeared to be well\u2010tolerated and effective with AEs typically mild, responsive to dose reduction, and similar to those reported in dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.70077","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T05:50:58Z","timestamp":1777269058000},"page":"557-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Retrospective Case Series Reporting the Clinical Efficacy and Adverse Events of Oclacitinib Administration for Skin Disease in 238 Cats"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0904-6943","authenticated-orcid":false,"given":"Marlyse R.","family":"Wehber","sequence":"first","affiliation":[{"name":"Pet Dermatology Clinic  Maple Grove Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa C.","family":"Eisenschenk","sequence":"additional","affiliation":[{"name":"Pet Dermatology Clinic  Maple Grove Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-3857","authenticated-orcid":false,"given":"Amanda J.","family":"Young","sequence":"additional","affiliation":[{"name":"Pet Dermatology Clinic  Maple Grove Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3944-1597","authenticated-orcid":false,"given":"Sandra N.","family":"Koch","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Sciences University of Minnesota  Saint Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12899"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2011.00962.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12933"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01086.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2011.00983.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12018"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X231220848"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(97)50027-1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2008.00717.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X20943522"},{"key":"e_1_2_10_12_1","first-page":"1051","article-title":"Incidences of Steroid\u2010Induced Diabetes Mellitus and Congestive Heart Failure in Cats Given Non\u2010Immunosuppressive Doses of Methylprednisolone Acetate: 1042 Cats","volume":"64","author":"Dutch W. 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