{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:17:32Z","timestamp":1789168652942,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n This study was performed to retrospectively evaluate the efficacy of oclacitinib (OC) (Apoquel; Zoetis) as a treatment option for pemphigus foliaceus (PF), pemphigus vulgaris (PV) and mucous membrane pemphigoid (MMP).<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To determine if OC can reduce or replace the corticosteroid use in dogs with PF, PV and MMP.<\/jats:p>\n <\/jats:sec>\n \n Animals<\/jats:title>\n There were no animal subjects.<\/jats:p>\n <\/jats:sec>\n \n Procedure<\/jats:title>\n Multicentre retrospective study reviewing medical records from two institutions for dogs diagnosed with PF, PV or MMP and prescribed OC between 2014 and 2025.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Twenty\u2010one dogs diagnosed with PF, PV or MMP via histopathological results were included. OC alone was effective in eight of 18 PF dogs at a median dose of 0.65\u2009mg\/kg\/day per os (range 0.5\u20131.9\u2009mg\/kg\/day p.o.). Five dogs reached clinical remission, and three reached partial remission. One PV dog and the MMP dog each reached clinical remission with OC alone at 0.7\u2009mg\/kg\/day and 0.24\u2009mg\/kg every other day, respectively. OC was a corticosteroid\u2010sparing agent or adjunctive therapy in seven of 18 PF dogs at a median dose of 0.6\u2009mg\/kg\/day (range 0.4\u20132.4\u2009mg\/kg\/day). One PV dog reached partial remission at OC 1.9\u2009mg\/kg\/day and prednisone 1.8\u2009mg\/kg\/day yet died from pancreatitis. OC was ineffective in three of 18 PF dogs at a median dose of 1.0\u2009mg\/kg\/day p.o. (range 0.9\u20131.2\u2009mg\/kg\/day p.o.). Statistical significance was not analysed.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Clinical Relevance<\/jats:title>\n OC is an effective sole therapeutic agent or adjunctive therapy in a subset of dogs with PF, PV or MMP. The long\u2010term safety of higher doses of OC is unknown.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vde.70078","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:16:02Z","timestamp":1777263362000},"page":"522-529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Treatment of Canine Pemphigus Foliaceus, Pemphigus Vulgaris and Mucous Membrane Pemphigoid With Oclacitinib: A Retrospective Analysis of 21 Cases"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2387-3917","authenticated-orcid":false,"given":"Breanna L.","family":"Scranton","sequence":"first","affiliation":[{"name":"University of Wisconsin\u2010Madison School of Veterinary Medicine Madison Wisconsin USA"},{"name":"Department of Medicine and Epidemiology, School of Veterinary Medicine University of California Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8994-1020","authenticated-orcid":false,"given":"Lara M.","family":"Tomich","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2010Madison School of Veterinary Medicine Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9998-4382","authenticated-orcid":false,"given":"Andrea T. H.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Medicine and Epidemiology, School of Veterinary Medicine University of California Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1118-9016","authenticated-orcid":false,"given":"Verena K.","family":"Affolter","sequence":"additional","affiliation":[{"name":"Department of Pathology Microbiology, Immunology, School of Veterinary Medicine, University California Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8181-4484","authenticated-orcid":false,"given":"Catherine A.","family":"Outerbridge","sequence":"additional","affiliation":[{"name":"Department of Medicine and Epidemiology, School of Veterinary Medicine University of California Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2003.00347.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13063"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12344"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2004.00379.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2004.224.1312"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12101"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12992"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12458"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12743"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12852"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13203"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12949"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119278368.ch7.2"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2023.110631"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.11.008"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.70078","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vde.70078","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.70078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T05:43:08Z","timestamp":1783834988000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.70078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,26]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/vde.70078"],"URL":"https:\/\/doi.org\/10.1111\/vde.70078","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,26]]},"assertion":[{"value":"2025-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}