{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:10:27Z","timestamp":1789171827670,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Superficial pyoderma is common in dogs with atopic dermatitis, yet no validated and widely accepted severity scoring system exists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To develop a predictor for superficial pyoderma severity based on reliable objective lesion quantification combined with a clinician\u2010assigned numerical severity rating.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Sixty client\u2010owned dogs presenting with follicular papules, pustules, epidermal collarettes, and\/or yellow crusts were prospectively enrolled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Six clinicians assessed lesion types, numerical and categorical disease severity, and treatment efficacy at baseline and at up to two follow\u2010up visits. Lesions were quantified by counting individual papules and pustules, and by standardised area measurements for confluent papules\/pustules, epidermal collarettes and crusts. Inter\u2010 and intra\u2010clinician reliability were evaluated. A predictive model for pyoderma severity was subsequently developed using lesion quantification and clinician\u2010assigned numerical severity scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Recognition of specific lesion types and categorical severity assessments showed poor agreement between clinicians, indicating limited reliability for severity assessment. By contrast, combined lesion quantification demonstrated good inter\u2010 and intra\u2010clinician reliability, and clinician\u2010assigned numerical severity scores showed good inter\u2010clinician reliability. The resulting predictive model demonstrated good agreement with clinician\u2010assigned severity scores, estimating pyoderma severity on a continuous scale from 0 (no pyoderma) to 100 (worst conceivable pyoderma), with a mean absolute error of approximately nine severity points per case.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>The proposed scoring system relies on combined lesion quantification without the need for subjective categorical grading. Although further validation is required, it provides a foundation for objective assessment of superficial pyoderma severity and introduces a mathematical model that translates combined lesion burden into clinician\u2010perceived disease severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.70086","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:15:34Z","timestamp":1783685734000},"page":"609-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Standardising Assessment of Superficial Pyoderma in Dogs: Proposal of a Severity Score"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6215-7704","authenticated-orcid":false,"given":"Micka\u00ebl","family":"Pinto","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1781-0969","authenticated-orcid":false,"given":"David","family":"Grass","sequence":"additional","affiliation":[{"name":"Department of Chemistry Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2772-9144","authenticated-orcid":false,"given":"Ina","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01050.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13342"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2736\/jjvd.14.71"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2006.00512.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2007.00363.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.233.3.433"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00785.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2010.00898.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.d4400"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12233"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12374"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-6628"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12808"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13038"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13031"},{"key":"e_1_2_11_17_1","first-page":"308","article-title":"In Vivo Efficacy of Clove Essential Oil Spray Formulation on Canine Superficial Pyoderma","volume":"44","author":"Aiemsaard J.","year":"2022","journal-title":"Songklanakarin Journal of Science and Technology"},{"key":"e_1_2_11_18_1","first-page":"647","article-title":"Topical Erythritol Combined With L\u2010Ascorbyl\u20102\u2010Phosphate Inhibits Staphylococcal Growth and Alleviates Staphylococcal Overgrowth in Skin Lesions of Canine Superficial Pyoderma","volume":"26","author":"Tochio T.","year":"2023","journal-title":"Polish Journal of Veterinary Sciences"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13323"},{"key":"e_1_2_11_20_1","first-page":"184","volume-title":"Muller and Kirk's Small Animal Dermatology, 7th Edition","author":"Miller W. H.","year":"2013"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12352"},{"key":"e_1_2_11_22_1","first-page":"57","volume-title":"Muller and Kirk's Small Animal Dermatology, 7th Edition","author":"Miller W. H.","year":"2013"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12118"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sapharm.2018.03.066"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-018-1569-y"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-010-9606-8"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcm.2016.02.012"},{"key":"e_1_2_11_28_1","first-page":"2825","article-title":"Scikit\u2010Learn: Machine Learning in Python","volume":"12","author":"Pedregosa F.","year":"2011","journal-title":"Journal of Machine Learning Research"},{"key":"e_1_2_11_29_1","article-title":"Fast Krippendorff: Fast Computation of Krippendorff's Alpha Agreement Measure","author":"Castro S.","year":"2017","journal-title":"GitHub Repos"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.21105\/joss.01026"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.1974.1100705"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-7152(96)00128-9"},{"key":"e_1_2_11_33_1","volume-title":"Model Selection and Multimodel Inference: A Practical Information\u2010Theoretic Approach","author":"Burnham K. P.","year":"2002"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2018.04.002"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.51258"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.11.1417"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08112.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13846"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2012.09.004"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjae.2019.03.002"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.70086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vde.70086","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.70086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:30:16Z","timestamp":1789169416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.70086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/vde.70086"],"URL":"https:\/\/doi.org\/10.1111\/vde.70086","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]},"assertion":[{"value":"2026-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}