{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:11:42Z","timestamp":1789171902368,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Equine aural plaques are a benign form of auricular papillomatosis caused by equine papillomavirus. Despite the efficacy of 5% imiquimod cream, a marked local reaction is frequently observed during therapy, often requiring sedation before application.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the efficacy and potential adverse effects of 0.5% topical tretinoin in the treatment of equine aural plaques. We hypothesised that tretinoin would be effective, with fewer adverse effects compared to imiquimod.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>The study included 10 horses of both sexes, aged between 7\u2009months and 15\u2009years, diagnosed with unilateral or bilateral aural plaques (totalling 17 ears).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This was a controlled clinical trial. Three horses underwent a pilot study, in which only one ear per animal was treated to allow for intra\u2010animal comparison, while the remaining seven horses received treatment in both ears. Lesions were classified into three groups based on the percentage of the inner auricular surface affected. Treatment was performed with 0.5% topical tretinoin once daily until lesion stabilisation or resolution. Lesion characteristics, treatment response, adverse effects and recurrence were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty\u2010five percent of the ears exhibited an improvement of &gt;\u200950% following treatment. On average, maximal lesion resolution occurred within 52.8\u2009days (range 6\u201374\u2009days). None of the horses exhibited severe sensitivity during the treatment period, allowing for ear manipulation throughout the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>The topical application of 0.5% tretinoin cream proved to be an effective and safe treatment for equine aural plaques. Further studies with a larger sample size and long\u2010term follow\u2010up are recommended to optimise treatment protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.70090","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:53:47Z","timestamp":1780106027000},"page":"664-671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of 0.5% Tretinoin in the Treatment of Equine Aural Plaques"],"prefix":"10.1111","volume":"37","author":[{"given":"Felipe Sperandio","family":"de Mattos","sequence":"first","affiliation":[{"name":"Departament of Veterinary Medicine Federal University of Vi\u00e7osa (UFV)  Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lissandro Gon\u00e7alves","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Departament of Veterinary Medicine Federal University of Vi\u00e7osa (UFV)  Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ytalo Galinari Henrique","family":"Schuartz","sequence":"additional","affiliation":[{"name":"Departament of Veterinary Medicine Federal University of Vi\u00e7osa (UFV)  Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vit\u00f3ria R\u00e9gia Melo","family":"Silva","sequence":"additional","affiliation":[{"name":"Departament of Veterinary Medicine Federal University of Vi\u00e7osa (UFV)  Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia Fernandes","family":"Fid\u00e9lis","sequence":"additional","affiliation":[{"name":"Departament of Veterinary Medicine Federal University of Vi\u00e7osa (UFV)  Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Campos","family":"Mansur","sequence":"additional","affiliation":[{"name":"FAMINAS University Center  Muria\u00e9 Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian Silva","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Departament of Animal Science Federal University of Vi\u00e7osa (UFV)  Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2931-6442","authenticated-orcid":false,"given":"Yame Fabres Robaina","family":"Sancler\u2010Silva","sequence":"additional","affiliation":[{"name":"Departament of Animal Science Federal University of Vi\u00e7osa (UFV)  Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Paes","family":"Oliveira\u2010Filho","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Science S\u00e3o Paulo State University (Unesp), school of Veterinary Medicine and Animal Science  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Secorun","family":"Borges","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Science S\u00e3o Paulo State University (Unesp), school of Veterinary Medicine and Animal Science  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana Raach","family":"Bromberger","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Science S\u00e3o Paulo State University (Unesp), school of Veterinary Medicine and Animal Science  Botucatu Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Dantas Ribeiro","family":"Filho","sequence":"additional","affiliation":[{"name":"Departament of Veterinary Medicine Federal University of Vi\u00e7osa (UFV)  Vi\u00e7osa Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel Ferreira 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