{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:10:37Z","timestamp":1789171837435,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fluorescent light energy (FLE; Phovia, Vetoquinol) is a photobiomodulation therapy that promotes healing and reduces inflammation. Cutaneous epitheliotropic lymphoma (CTCL) is a neoplastic skin disease with limited treatment options. Although FLE is not considered genotoxic, its use in neoplastic conditions is off\u2010label.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>To assess the safety and clinical effect of FLE as an adjunctive treatment for canine CTCL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Eight client\u2010owned dogs were diagnosed with CTCL via biopsy analysis and immunohistochemical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Each dog had one CTCL lesion treated with FLE with a lesion serving as a vehicle\u2010control. Treatments were administered weekly for 6\u2009weeks, followed by 3\u2009months follow\u2010up. Focal nodular lesions were assessed weekly using Response Evaluation Criteria of Solid Tumours (RECIST), while diffuse lesions were evaluated using the Canine Epitheliotropic Lymphoma Extent and Severity Index (CELESI). Owner\u2010perceived efficacy and quality of life were assessed using the Owner Global Assessment of Treatment Efficacy (OGATE) and a quality\u2010of\u2010life (QoL) survey.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No statistically significant differences in estimated marginal means were observed between sites at any time point (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Within\u2010subject analyses suggested more favourable lesion progression at FLE\u2010treated sites, and 75% of RECIST\u2010evaluated FLE lesions maintained stable disease. Diffuse FLE\u2010treated lesions demonstrated clinical severity reductions of \u2264\u200935.3%. Over 66% of owners rated treatment response as \u2018fair\u2019 to \u2018excellent\u2019 on the OGATE. One dog was withdrawn at Week 3 as a consequence of unrelated worsening.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>FLE appears to be a safe adjunctive therapy for canine CTCL, although statistically significant treatment effects were not demonstrated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.70098","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T06:58:44Z","timestamp":1782543524000},"page":"788-796","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fluorescent Light Energy (\n                    <scp>FLE<\/scp>\n                    ) as an Adjunctive Therapy in Canine Cutaneous Epitheliotropic Lymphoma (\n                    <scp>CTCL<\/scp>\n                    )"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9707-1517","authenticated-orcid":false,"given":"S.","family":"Nowell","sequence":"first","affiliation":[{"name":"Animal Dermatology Clinic  Greenville South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Fantini","sequence":"additional","affiliation":[{"name":"Vetoquinol S.A.  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Roman","sequence":"additional","affiliation":[{"name":"Vetoquinol S.A.  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Milley","sequence":"additional","affiliation":[{"name":"Animal Dermatology Clinic  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Watson","sequence":"additional","affiliation":[{"name":"Animal Dermatology Clinic  Greenville South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Animal Dermatology Clinic  Greenville South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"421","article-title":"Canine Cutaneous Epitheliotropic Lymphoma (Mycosis Fungoides) is a Proliferative Disorder of CD8+ T Cells","volume":"144","author":"Moore P. F.","year":"1994","journal-title":"American Journal of Pathology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/03009858221140818"},{"key":"e_1_2_11_4_1","first-page":"281","article-title":"Cutaneous T\u2010Cell Epitheliotropic Lymphoma","volume":"64","author":"Pye C.","year":"2023","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2008.00176.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12785"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6643416"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/med-2021-0329"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12890"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2334"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13814"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S185798"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels9040286"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1396-0296.2003.01642.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1992.01680170063007"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13280"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-018-1569-y"},{"key":"e_1_2_11_18_1","article-title":"Instruments to Assess Disease\u2010Specific Quality of Life in Dogs: A Scoping Review","volume":"15","author":"Rhein F. 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