{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:11:58Z","timestamp":1789171918418,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010282","name":"Harry M. Zweig Memorial Fund for Equine Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010282","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gammaherpesviruses have been associated with granulomatous inflammation in the skin of various species. Equine sarcoidosis (idiopathic granulomatous disease) can cause granulomatous dermatitis, and its cause remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This retrospective study aimed to investigate the possible association between equine gammaherpesviruses\u20102 and \u20105 (EHV\u20102, \u20105) and cutaneous equine sarcoidosis (cES).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirty client\u2010owned equids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      All animals had histologically and clinically confirmed cES. Signalment, geographical location and clinical features were recorded. Gram, Ziehl\u2013Nielsen and Grocott\u2013G\u00f6m\u00f6ri methenamine silver histochemical stains, quantitative (q)PCR and\n                      <jats:italic>in situ<\/jats:italic>\n                      hybridisation were performed on formalin\u2010fixed paraffin\u2010embedded tissue samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Quarter horses and thoroughbreds were overrepresented, and ages ranged from 10\u2009months to 31\u2009years old, with minimal difference in sex distribution. Localised, partially generalised, and generalised forms were noted in 13, 11 and six animals, respectively. The most common lesions were alopecia, crust and scale, and the limbs were the most affected site. Neither bacteria nor fungi were detected with histochemical stains. EHV\u20105 and \u20102 DNA were detected by qPCR in eight and four of 30 animals, respectively. Of those eight horses, EHV\u20105 hybridisation signals were found within skin lesions of five. ISH did not detect EHV\u20102 in any of the 29 animals tested.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Relevance<\/jats:title>\n                    <jats:p>Although the exact cause of sarcoidosis remains uncertain, these findings suggest that EHV\u20105 may play some role in the pathogenesis of cES. This study also reports a single case of cES in a donkey.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.70101","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:11:26Z","timestamp":1783127486000},"page":"688-699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cutaneous Equine Sarcoidosis: A Case Series and Investigation Into a Potential Association With Equine Gammaherpesviruses\u20102 and \u20105 in 30 Equids"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3499-9433","authenticated-orcid":false,"given":"Celine","family":"Garandeau","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Cornell University, College of Veterinary Medicine  Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0864-4236","authenticated-orcid":false,"given":"Christopher P.","family":"Champion","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences Cornell University, College of Veterinary Medicine  Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manigandan","family":"Lejeune","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences Cornell University, College of Veterinary Medicine  Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9610-9040","authenticated-orcid":false,"given":"Jeanine","family":"Peters\u2010Kennedy","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences Cornell University, College of Veterinary Medicine  Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2012.01108.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2013.08.004"},{"key":"e_1_2_11_4_1","first-page":"453","volume-title":"Equine Dermatology","author":"Scott D. 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