{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:27:02Z","timestamp":1786116422635,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Symmetrical lupoid onychodystrophy (SLO) is a complex disease that exclusively affects the claws of dogs and represents a therapeutic challenge. Biopsy sampling of the third phalanx for histopathological evaluation has historically been the recommended diagnostic test, yet clinical diagnosis is currently encouraged. Numerous treatment protocols of varying success have been proposed for dogs with this condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The goals of this study are to report clinical findings, treatment protocols and outcomes of dogs with SLO, to propose a rationale for the clinical diagnosis and to discuss therapies for SLO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirty\u2010one dogs examined at a veterinary hospital from May 2004 to April 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of medical records from dogs diagnosed with SLO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The average age of dogs at disease onset and diagnosis was 7\u2009years old. Nineteen breeds were represented. Thirty dogs were clinically diagnosed with SLO, mostly presenting with onychodystrophy and onychomadesis, and in one a biopsy sample was collected. Different therapeutic combinations including tetracyclines alone or with niacinamide, pentoxifylline, essential fatty acids (EFAs), vitamin E, biotin and ciclosporin were used for the initial and\/or maintenance treatment of SLO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>The distinctive presentation of SLO supports its clinical diagnosis. Medical treatment seems to support a favourable long\u2010term outcome, despite the wide variation in protocols and doses. EFAs were commonly used as initial and maintenance therapy, and tetracyclines could often be excluded from the treatment protocol, thus complying with good antimicrobial stewardship practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.70114","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T09:51:16Z","timestamp":1786009876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Symmetrical Lupoid Onychodystrophy in Review: Lessons Learned From 31 Cases"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7623-7301","authenticated-orcid":false,"given":"Jessica R.","family":"Calesso","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinic and Surgery, College of Veterinary Medicine Universidade Federal de Minas Gerais  Belo Horizonte Brazil"},{"name":"Department of Veterinary Clinical Medicine, College of Veterinary Medicine University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9455-7867","authenticated-orcid":false,"given":"Clarissa P.","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine, College of Veterinary Medicine University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0002-0987","authenticated-orcid":false,"given":"Stephanie R.","family":"Bruner","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine, College of Veterinary Medicine University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8995-9805","authenticated-orcid":false,"given":"Adriane P. C. V.","family":"Bicalho","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinic and Surgery, College of Veterinary Medicine Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.12968\/coan.2013.18.4.165","article-title":"Claw Disease in Dogs: Part 1 \u2013 Anatomy and Diagnostic Approach","volume":"18","author":"Warren S.","year":"2013","journal-title":"Companion Animal"},{"key":"e_1_2_9_3_1","first-page":"880","article-title":"Symmetric Lupoid Onychodystrophy (SLO)","volume":"64","author":"Quilling L. 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