{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:06:05Z","timestamp":1789034765150,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Radiation\u2010induced alopecia (RIA) is a common adverse effect of radiation therapy, yet factors influencing its development in dogs remain unclear.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To characterise acute RIA in dogs with nasal tumours and to evaluate associations with coat type and radiation dose.<\/jats:p>\n <\/jats:sec>\n \n Animals<\/jats:title>\n Thirty\u2010eight client\u2010owned dogs were treated with radiation therapy for nasal tumours.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n Medical records were reviewed retrospectively. Dogs were classified by coat type (straight versus curly or wire\u2010haired). Time to onset of alopecia was assessed as the interval from the first irradiation to the first detection of alopecia, and cumulative skin dose was calculated up to alopecia onset. Dogs developing acute RIA during radiation therapy were compared with those without RIA. Dogs developing alopecia only after completion of radiation therapy were excluded.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Seventeen of 34 dogs developed acute RIA during radiation therapy. Coat type was significantly associated with RIA development (\n p<\/jats:italic>\n \u2009=\u20090.003), with all dogs with curly or wire\u2010haired coats affected. These dogs developed RIA earlier than those with straight\u2010haired coats (median 14 versus 20\u2009days;\n p<\/jats:italic>\n \u2009=\u20090.047). Within affected dogs, RIA developed first in regions receiving higher skin doses and subsequently progressed to regions receiving lower skin doses.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Clinical Relevance<\/jats:title>\n Coat type influences the development of acute RIA in dogs, with curly or wire\u2010haired breeds showing earlier onset and greater extent of alopecia. Alopecia progression reflects regional skin dose distribution. These findings may assist clinicians in predicting the risk of RIA and informing owners about the potential development and timing of radiation\u2010induced alopecia.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vde.70126","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:06:46Z","timestamp":1789031206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiation\u2010Induced Alopecia in Dogs With Nasal Tumours: Coat Type Influences Development and Onset"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0407-9452","authenticated-orcid":false,"given":"Yuki","family":"Nemoto","sequence":"first","affiliation":[{"name":"Department of Veterinary Radiology, Joint Faculty of Veterinary Medicine Yamaguchi University Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1200-9272","authenticated-orcid":false,"given":"Kirara","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Veterinary Radiology, Joint Faculty of Veterinary Medicine Yamaguchi University Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6100-1610","authenticated-orcid":false,"given":"Aoi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Veterinary Radiology, Joint Faculty of Veterinary Medicine Yamaguchi University Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2793-4987","authenticated-orcid":false,"given":"Hirona","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Veterinary Radiology, Joint Faculty of Veterinary Medicine Yamaguchi University Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6274-7228","authenticated-orcid":false,"given":"Munekazu","family":"Nakaichi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Radiology, Joint Faculty of Veterinary Medicine Yamaguchi University Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.13173"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.03.055"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.13291"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.13065"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12409"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13566-012-0051-x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.2127"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2009.01545.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1177808"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2011.00963.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2004.00386.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02214896"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.70126","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vde.70126","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.70126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:06:47Z","timestamp":1789031207000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.70126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":12,"alternative-id":["10.1111\/vde.70126"],"URL":"https:\/\/doi.org\/10.1111\/vde.70126","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]},"assertion":[{"value":"2026-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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