{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:03:33Z","timestamp":1791468213526,"version":"4.3.4"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bovine colostrum (BC) shows immunomodulatory properties, which could be beneficial in the management of chronic immune\u2010mediated diseases such as canine atopic dermatitis (cAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess if a BC supplementation affects selected immune variables and clinical signs in cAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty client\u2010owned dogs with non\u2010seasonal, environmentally induced cAD were enrolled in this prospective, double\u2010blinded, placebo\u2010controlled study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>After a 2\u2010week adaptation to standardised feeding, the dogs were divided into two groups, receiving either a placebo or BC at 0.2% in dietary dry matter for 4\u2009weeks. Afterwards, the dogs remained on their diets for another 4\u2009weeks, without placebo and BC supplementation. Blood and faecal samples were collected on Day (D)14, D42 and D70 for immunological measurements (proliferative and phagocytic activity of blood leukocytes, faecal immunoglobulin [Ig]A, plasma concentrations of Igs, C\u2010reactive protein [CRP] and serum amyloid A [SAA]). Additionally, the Canine Atopic Dermatitis Extent and Severity Index, 4th iteration (CADESI\u201004) was assessed. The owners evaluated pruritus (Visual Analog Scale) of their dogs retrospectively and daily (r\u2212\/d\u2010pVAS), as well as quality\u2010of\u2010life (QoL), global assessment and quality\u2010of\u2010coat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant diet effects were detected for the clinical and immunological parameters evaluated. A slight improvement in QoL could be observed in both feeding groups over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>An oral administration of BC did not alter relevant clinical and immune parameters in patients with cAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vde.70132","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:32:55Z","timestamp":1791466375000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of a Dietary Supplementation of Bovine Colostrum in Dogs With Atopic Dermatitis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8713-4065","authenticated-orcid":false,"given":"Laura","family":"Sch\u00e4fer","sequence":"first","affiliation":[{"name":"Clinic for Small Animals, Internal Medicine Justus\u2010Liebig\u2010University Giessen  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"B\u00fcttner","sequence":"additional","affiliation":[{"name":"Unit for Biomathematics and Data Processing Justus\u2010Liebig\u2010University Giessen  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Pa\u00dflack","sequence":"additional","affiliation":[{"name":"Clinic for Small Animals, Internal Medicine Justus\u2010Liebig\u2010University Giessen  Giessen Germany"},{"name":"Chair of Animal Nutrition and Dietetics Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen  Oberschlei\u00dfheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/vde.13210","article-title":"Update on the Role of Genetic Factors, Environmental Factors and Allergens in Canine Atopic Dermatitis","volume":"35","author":"Hensel P.","year":"2024","journal-title":"Veterinary Dermatology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0165-2427(01)00296-3","article-title":"The ACVD Task Force on Canine Atopic Dermatitis (I): Incidence and Prevalence","volume":"81","author":"Hillier A.","year":"2001","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.2460\/javma.254.11.1291","article-title":"Update on Pathogenesis, Diagnosis, and Treatment of Atopic Dermatitis in Dogs","volume":"254","author":"Nuttall T. 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