{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:42:01Z","timestamp":1792658521278,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Dermatology"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Canine atopic dermatitis (cAD) is a chronic allergic inflammatory skin disease that requires multimodal management. Allogeneic mesenchymal stromal cells (MSCs) have emerged as a potential therapeutic option.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate the efficacy and safety of an investigational allogeneic adipose\u2010derived MSC product (PK\/CM\u20101) in dogs with cAD.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n Dogs with mild\u2010to\u2010moderate cAD were enrolled in a single\u2010blind, randomised study and allocated in a 2:1 ratio either to an experimental group (receiving a single intravenous dose of PK\/CM\u20101) or a control group (receiving three monthly subcutaneous doses of lokivetmab). Clinical outcomes were assessed using the Canine Atopic Dermatitis Extent and Severity Index, 4th iteration (CADESI\u201004) and pruritus Visual Analog Scale (PVAS) scores on Day (D)28 (primary end\u2010point) and D7, D56 and D84. Safety assessments included haematological and biochemical analyses on D84, along with monitoring for adverse events.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Thirty\u2010two dogs were included. By D28, both CADESI\u201004 and PVAS scores had significantly decreased from baseline in both groups. No significant differences between groups were observed on D28 (\n p<\/jats:italic>\n \u2009=\u20090.696 and\n p<\/jats:italic>\n \u2009=\u20090.088, respectively). Clinical improvement was sustained up to D84. In the experimental group, CADESI\u201004 and PVAS scores were lower on D84 than on D28 (\n p<\/jats:italic>\n \u2009=\u20090.0074 and\n p<\/jats:italic>\n \u2009=\u20090.0015, respectively). Two adverse events (one severe and one mild) occurred during PK\/CM\u20101 administration. No clinically significant haematological or biochemical abnormalities were observed.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Clinical Relevance<\/jats:title>\n PK\/CM\u20101 demonstrated comparable efficacy and safety to those of lokivetmab over a 3\u2009month period. Careful monitoring is recommended during intravenous administration of PK\/CM\u20101.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vde.70136","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:22:17Z","timestamp":1792657337000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Allogeneic Mesenchymal Stromal Cells Versus Lokivetmab in Mild\u2010To\u2010Moderate Canine Atopic Dermatitis: A Single\u2010Blind Randomised Study"],"prefix":"10.1111","author":[{"given":"Marta","family":"Pasikowska","sequence":"first","affiliation":[{"name":"Bioceltix S.A. Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagoda","family":"Ciszewska\u2010Ceran","sequence":"additional","affiliation":[{"name":"Department of Clinical Diagnostics and Veterinary Dermatology, Faculty of Veterinary Medicine University of Life Sciences in Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Cekiera","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine Wroc\u0142aw University of Environmental and Life Sciences Wroc\u0142aw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Gocek","sequence":"additional","affiliation":[{"name":"Bioceltix S.A. Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0012-1227","authenticated-orcid":false,"given":"Jakub","family":"Grzesiak","sequence":"additional","affiliation":[{"name":"Bioceltix S.A. Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6881-4831","authenticated-orcid":false,"given":"Patryk","family":"Reniewicz","sequence":"additional","affiliation":[{"name":"Bioceltix S.A. Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5000-2843","authenticated-orcid":false,"given":"Jaros\u0142aw","family":"Popiel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine Wroc\u0142aw University of Environmental and Life Sciences Wroc\u0142aw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3650-5356","authenticated-orcid":false,"given":"Marcin","family":"Szczepanik","sequence":"additional","affiliation":[{"name":"Department of Clinical Diagnostics and Veterinary Dermatology, Faculty of Veterinary Medicine University of Life Sciences in Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2997-3186","authenticated-orcid":false,"given":"Piotr","family":"Wilko\u0142ek","sequence":"additional","affiliation":[{"name":"Department of Clinical Diagnostics and Veterinary Dermatology, Faculty of Veterinary Medicine University of Life Sciences in Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3390\/vetsci9040149","article-title":"Clinical Guidelines for the Use of Antipruritic Drugs in the Control of the Most Frequent Pruritic Skin Diseases in Dogs","volume":"9","author":"Bruet V.","year":"2022","journal-title":"Veterinary Sciences"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13601-018-0228-5","article-title":"Atopic Dermatitis in Cats and Dogs: A Difficult Disease for Animals and Owners","volume":"8","author":"Gedon N. 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Can a Monoclonal Antibody Blocking a Single Cytokine Prevent Allergy Flares?","volume":"30","author":"Tamamoto\u2010Mochizuki C.","year":"2019","journal-title":"Veterinary Dermatology"},{"key":"e_1_2_9_35_1","doi-asserted-by":"crossref","DOI":"10.1111\/vde.12984","article-title":"A Masked, Randomised Clinical Trial Evaluating the Efficacy and Safety of Lokivetmab Compared to Saline Control in Client\u2010Owned Dogs With Allergic Dermatitis","volume":"32","author":"Van Brussel L.","year":"2021","journal-title":"Veterinary Dermatology"}],"container-title":["Veterinary Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.70136","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vde.70136","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vde.70136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:22:22Z","timestamp":1792657342000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vde.70136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":34,"alternative-id":["10.1111\/vde.70136"],"URL":"https:\/\/doi.org\/10.1111\/vde.70136","archive":["Portico"],"relation":{},"ISSN":["0959-4493","1365-3164"],"issn-type":[{"value":"0959-4493","type":"print"},{"value":"1365-3164","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]},"assertion":[{"value":"2025-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"vde.70136"}}