{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:26:46Z","timestamp":1770438406936,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T00:00:00Z","timestamp":1362441600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2013,3]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To review what is known about the familial renal diseases in soft\u2010coated wheaten terriers (SCWT<\/jats:styled-content>), provide an update in developments in this field including the relationship with protein\u2010losing nephropathy (PLN<\/jats:styled-content>) and the potential association with protein\u2010losing enteropathy (PLE<\/jats:styled-content>).<\/jats:p><\/jats:sec>Data Sources<\/jats:title>Information was derived from studies of dogs maintained in the N<\/jats:styled-content>orth C<\/jats:styled-content>arolina S<\/jats:styled-content>tate U<\/jats:styled-content>niversity colony, information contained within an open registry of affected dogs, and data gathered from the general population of wheaten terriers at risk as well as studies performed on banked DNA<\/jats:styled-content> samples from affected SCWT<\/jats:styled-content> in the general population and normal geriatric dogs seen at the U<\/jats:styled-content>niversity of P<\/jats:styled-content>ennsylvania (P<\/jats:styled-content>ennV<\/jats:styled-content>et).<\/jats:p><\/jats:sec>Human Data Synthesis<\/jats:title>A two\u2010hit pathogenesis has been proposed in some types of human focal segmental glomerulosclerosis, specifically the subset of cases that are associated with a podocytopathy. At risk podocytes may be predisposed to injury by disease processes that would be reversible in other patients.<\/jats:p><\/jats:sec>Veterinary Data Synthesis<\/jats:title>Mutations were found in association with PLN<\/jats:styled-content> in SCWT<\/jats:styled-content>, indicating a podocytopathy that causes a change in glomerular permselectivity. This podocytopathy leads to the development of lesions resembling focal segmental glomerulosclerosis. There is also strong evidence supporting a high prevalence of food hypersensitivity reactions in SCWT<\/jats:styled-content>, although it is unclear if these reactions have a primary or secondary role in the development of PLE<\/jats:styled-content>. There are also suggestions of immunodysregulation in affected SCWT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>PLN<\/jats:styled-content> in SCWT<\/jats:styled-content> is due to a podocytopathy. The cause of PLE<\/jats:styled-content> has not been identified; however, it is possible that PLE<\/jats:styled-content> develops from a functional\u2010structural abnormality in the intestines and food allergies develop as secondary phenomena. It is also possible that inflammatory events that are the result of either immunodysregulation or food allergies might lead to the development of PLE<\/jats:styled-content>. In either case, PLE<\/jats:styled-content> most likely exacerbates PLN<\/jats:styled-content> in affected SCWT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12027","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T17:45:03Z","timestamp":1362505503000},"page":"174-183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Familial renal disease in soft\u2010coated wheaten terriers"],"prefix":"10.1111","volume":"23","author":[{"given":"Shelly L.","family":"Vaden","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina University Raleigh NC 29607"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meryl P.","family":"Littman","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies\u2010Philadelphia, School of Veterinary Medicine University of Pennsylvania Philadelphia PA 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel E.","family":"Cianciolo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of North Carolina Chapel Hill NC 27599"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,5]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"68","article-title":"Familial protein\u2010losing enteropathy and protein\u2010losing nephropathy in Soft Coated Wheaten Terriers: 222 cases (1983\u20131997)","volume":"14","author":"Littman MP","year":"2000","journal-title":"J Vet Intern Med"},{"key":"e_1_2_10_3_1","unstructured":"LittmanMP SmagalaAJ.The open registry and DNA bank for soft\u2010coated wheaten terriers at theUniversity ofPennsylvaniaSchool ofVeterinaryMedicine. In:Proceedings of the 4th Tufts Canine and Feline Breeding and Genetics Conference;2009:Sturbridge MA USA."},{"key":"e_1_2_10_4_1","unstructured":"LittmanMP.WheatenPLE\u2010PLN. 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