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Fibroblast growth factor\u201023 is now considered to be a key regulator of plasma phosphorus concentration in people but has only recently been investigated in companion animal species.<\/jats:p><\/jats:sec><jats:sec><jats:title>Veterinary Data Synthesis<\/jats:title><jats:p>Cross\u2010sectional studies of naturally occurring<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>in dogs and cats have shown hyperphosphatemia and<jats:styled-content style=\"fixed-case\">SRHP<\/jats:styled-content>to be highly prevalent and associated with increased morbidity and mortality in these patients. Experimental studies of surgically induced renal impairment in the dog and cat, and cases of naturally occurring<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>have emphasized the ability of renal care diets to modify plasma phosphorus and parathyroid hormone concentrations. Evidence from these studies indicates that maintaining plasma phosphorus concentrations to within the International Renal Interest Society targets for<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>patients improves survival time and reduces clinical manifestations of hyperphosphatemia and<jats:styled-content style=\"fixed-case\">SRHP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The maintenance of plasma phosphorus concentrations in to within the International Renal Interest Society targets is recommended in management of<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>patients. The discovery of the phosphatonins has improved understanding of the mechanisms involved in phosphorus homeostasis and<jats:styled-content style=\"fixed-case\">SRHP<\/jats:styled-content>and may lead to improved ability to monitor and manage these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12032","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T19:02:01Z","timestamp":1362596521000},"page":"122-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["The role of phosphorus in the pathophysiology of chronic kidney disease"],"prefix":"10.1111","volume":"23","author":[{"given":"Rebecca F.","family":"Geddes","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences Royal Veterinary College Hawkshead Lane, North Mymms Hatfield AL9 7TA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie 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