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It is now apparent that calcitriol exerts an important effect on renal tubular reclamation of filtered 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)\u2010vitamin<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>, which may be important in maintaining adequate circulating 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)\u2010vitamin<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>. This in turn may be vital for important pleiotropic actions in peripheral tissues through autocrine\/paracrine mechanisms that impact the health of those local tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Veterinary Data Synthesis<\/jats:title><jats:p>Limited information is available reporting the benefit of calcitriol treatment in dogs and cats with<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A survival benefit has been shown for dogs with<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>treated with calcitriol compared to placebo. The concentrations of circulating 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)\u2010vitamin<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>have recently been shown to be low in people and dogs with<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>and are related to survival in people with<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>. Combination therapy for people with<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>using both parental and activated vitamin<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>compounds is common in human nephrology and there is a developing emphasis using combination treatment with activated vitamin<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>and renin\u2010angiotensin\u2010aldosterone\u2010system (<jats:styled-content style=\"fixed-case\">RAAS<\/jats:styled-content>) inhibitors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12036","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T12:30:08Z","timestamp":1365424208000},"page":"134-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Calcitriol, calcidiol, parathyroid hormone, and fibroblast growth factor\u201023 interactions in chronic kidney 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