{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:05:09Z","timestamp":1770217509125,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the diagnostic ability of blood N\u2010terminal pro B\u2010type natriuretic peptide (NT\u2010proBNP) measurement to differentiate between congestive heart failure (CHF) and noncardiogenic causes for moderate to severe pleural effusion in cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University teaching hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty\u2010one cats with moderate to severe pleural effusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>Venous blood sampling for NT\u2010proBNP measurement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurement and Results<\/jats:title><jats:p>According to the results of echocardiographic examination, cats were classified in a group with CHF (<jats:italic>n<\/jats:italic> = 11) or noncongestive heart failure (N\u2010CHF, <jats:italic>n<\/jats:italic> = 10). NT\u2010proBNP was measured via a feline\u2010specific test in EDTA plasma with protease inhibitor. NT\u2010proBNP was significantly (<jats:italic>P<\/jats:italic> &lt; 0.0001) higher in the CHF group ( median 982 pmol\/L, 355\u20131,286 pmol\/L) than in the N\u2010CHF group (median 69 pmol\/L, 26 \u2013 160 pmol\/L) and discriminated exactly (area under the curve = 1.0, 95% confidence interval 1.0\u20131.0) between both groups. Optimum cut\u2010off value considering all samples was 258 pmol\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this small population of cats with pleural effusion, NT\u2010proBNP was able to differentiate between cats with cardiogenic and noncardiogenic causes of effusion. With the currently recommended method of measurement (ie, EDTA plasma with protease inhibitor), a cut\u2010off value of 258 pmol\/L discriminates effectively between cats with and without CHF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12074","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T17:24:43Z","timestamp":1373995483000},"page":"416-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Assessment of circulating N\u2010terminal pro B\u2010type natriuretic peptide concentration to differentiate between cardiac from noncardiac causes of pleural effusion in cats"],"prefix":"10.1111","volume":"23","author":[{"given":"Esther","family":"Hassdenteufel","sequence":"first","affiliation":[{"name":"Department of Clinical Studies Small Animal Clinic, University of Giessen  35392 Giessen 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