{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:11:08Z","timestamp":1770221468349,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T00:00:00Z","timestamp":1376352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe 2 cases of vasculitis that were attributed to a type III hypersensitivity reaction in critically ill dogs occurring 8\u201316 days postadministration of human serum albumin (HSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Case or Series Summary<\/jats:title><jats:p>Skin biopsies were obtained from 3 different sites in 2 critically ill dogs that developed vasculitis 8\u201316 days following treatment with HSA. Histopathological findings from both dogs indicated epidermal pallor, widespread edema and hemorrhage, degenerative neutrophilic perivascular infiltrates, and multifocal areas of neutrophilic or leukocytoclastic vasculitis. Immunohistochemical staining using an anti\u2010human serum albumin rabbit antibody suggested that the antigen\u2010antibody complexes seen in the dermis were associated with the administration of HSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>New or Unique Information Provided<\/jats:title><jats:p>In this case series, we documented a leukocytoclastic vasculitis and probable antigen\u2010antibody complexes to human albumin in the dermis of 2 critically ill dogs after administration of HSA. Previously, type III hypersensitivity reactions had only been reported in healthy dogs that had received HSA. This report also describes the potential use of immunohistochemical staining to detect the HSA antigen in tissue sections through the use of specifically labeled antibodies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12085","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T20:48:39Z","timestamp":1376426919000},"page":"598-604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Type III hypersensitivity reaction with immune complex deposition in 2 critically ill dogs administered human serum albumin"],"prefix":"10.1111","volume":"23","author":[{"given":"Cassandra","family":"Powell","sequence":"first","affiliation":[{"name":"VCA All Care Animal Referral Center  Fountain Valley CA 92708"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Thompson","sequence":"additional","affiliation":[{"name":"Center for Vet Specialty Care  Carrollton TX 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