{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:04:59Z","timestamp":1771063499350,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T00:00:00Z","timestamp":1378684800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate a population of cats with selective\u2010serotonin reuptake inhibitor (SSRI) toxicosis and characterize the population affected, list products ingested, the clinical signs observed, treatments performed, length of hospitalization, patient outcome, and overall prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective study from 2004 to 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Referral veterinary center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Thirty\u2010three witnessed cat SSRI ingestions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>None.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Main Results<\/jats:title><jats:p>The medical records of cats with a witnessed SSRI ingestion identified by review of an animal poison control center electronic database were evaluated. The most common SSRIs ingested were venlafaxine (Effexor; 12\/33; 36%), fluoxetine (Prozac; 12\/33; 36%), citalopram (Celexa; 6\/33; 18%), and escitalopram (Lexapro; 3\/33; 9%). Overall, 24% of cats (8\/33) became symptomatic, while 76% (25\/33) remained asymptomatic. Of the symptomatic cats, sedation was the most common clinical sign (6\/8; 75%), followed by gastrointestinal signs (4\/8; 50%), central nervous system stimulation (1\/8; 13%), cardiovascular signs (1\/8; 13%), and hyperthermia (1\/8; 13%). Veterinary care was sought in 20 cats (20\/33; 61%). Sixteen cats (16\/20; 80%) were hospitalized, while 4 cats (4\/20; 20%) were treated as outpatients. Treatment for hospitalized patients included administration of IV fluid therapy (14\/16; 88%), activated charcoal (12\/16; 75%), anti\u2010arrhythmic agents (7\/16; 44%), methocarbamol (6\/16; 38%), cyproheptadine (6\/16; 38%), anti\u2010emetics (5\/16; 31%), and sedation (5\/16; 31%). Diagnostics included blood work (7\/16; 44%), blood pressure measurement (3\/16; 19%), and electrocardiogram monitoring (2\/16; 13%). Mean hospitalization time for all cases of SSRI ingestion was 14.6 \u00b1 7.8 hours (<jats:italic>n<\/jats:italic> = 16). All symptomatic cats in this study (8\/8; 100%) had resolution of clinical signs and survived to discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prognosis for SSRI ingestion in this population of cats was excellent. Decontamination and supportive care for at least 12\u201324 hours can be considered in cats with SSRI ingestion, particularly venlafaxine to monitor resolution of clinical signs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vec.12091","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T19:12:14Z","timestamp":1378753934000},"page":"565-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Selective serotonin reuptake inhibitor (SSRI) toxicosis in cats: 33 cases (2004\u20132010)"],"prefix":"10.1111","volume":"23","author":[{"given":"Cassandra M.","family":"Pugh","sequence":"first","affiliation":[{"name":"Department of Emergency and Critical Care Ocean State Veterinary Specialists  1480 South County Trail East Greenwich RI 02818"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph T.","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Ocean State Veterinary Specialists  1480 South County Trail East Greenwich RI 02818"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Bloch","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Bridgewater State University  Bridgewater MA 02325"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine A.","family":"Lee","sequence":"additional","affiliation":[{"name":"Pet Poison Helpline  3600 American Boulevard W, Suite 700 Bloomington MN 55431"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Ocean State Veterinary Specialists  1480 South County Trail East Greenwich RI 02818"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn R.","family":"Hovda","sequence":"additional","affiliation":[{"name":"Pet Poison Helpline  3600 American Boulevard W, Suite 700 Bloomington MN 55431"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2008.00944.x"},{"key":"e_1_2_7_3_1","first-page":"520","article-title":"Antidepressant drug overdoses in dogs","volume":"95","author":"Wismer TA","year":"2000","journal-title":"Vet Med"},{"key":"e_1_2_7_4_1","first-page":"195","volume-title":"Blackwell's Five\u2010Minute Veterinary Consult Clinical Companion: Small Animal Toxicology","author":"Sioris KM","year":"2011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1081\/CLT-120037428"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg109"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(98)00057-2"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0704(05)70368-7"},{"issue":"9","key":"e_1_2_7_9_1","first-page":"490","article-title":"Understanding behavior: serotonin syndrome","volume":"30","author":"Crowell\u2010Davis SL","year":"2008","journal-title":"Compend Contin Educ Vet"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.235.6.705"},{"issue":"1","key":"e_1_2_7_11_1","first-page":"18","article-title":"Effects of reconcile (fluoxetine) chewable tablets plus behavior management for canine separation anxiety","volume":"8","author":"Simpson B","year":"2007","journal-title":"Vet Ther"},{"key":"e_1_2_7_12_1","volume-title":"Top 200 Prescription Drugs of 2008","author":"Lamb E","year":"2009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.153.3.311"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/026988119901300111"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2007.08.015"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2007.01.008"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2009.03382.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.216.1937"}],"container-title":["Journal of Veterinary Emergency and Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvec.12091","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.12091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T03:48:55Z","timestamp":1696045735000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vec.12091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/vec.12091"],"URL":"https:\/\/doi.org\/10.1111\/vec.12091","archive":["Portico"],"relation":{},"ISSN":["1479-3261","1476-4431"],"issn-type":[{"value":"1479-3261","type":"print"},{"value":"1476-4431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"2011-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}